Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-August 2010 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2010 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines

  • Authors:
    • Rosemarie ten Cate
    • Przemek Krawczyk
    • Jan Stap
    • Jacob A. Aten
    • Nicolaas A.P. Franken
  • View Affiliations / Copyright

    Affiliations: Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine, Department of Radiation Oncology, 1100 DE Amsterdam, The Netherlands. r.tencate@amc.uva.nl
  • Pages: 765-769
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ol_00000134
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Agents that enhance the effectiveness of ionizing radiation have been investigated over many decades. A relatively new group of potential radiosensitizers consists of agents that inhibit histone acetyltransferases (HATs). This study evaluated the radiosensitizing properties of the HAT inhibitor anacardic acid (AA), used at a low-toxic concentration of 100 µM in V79, SW1573 and U2OS cells. Radiation survival curves were analyzed according to the linear quadratic model. Significant radiosensitization by AA was only obtained in U2OS cells. AA significantly increased the value of the linear parameter α, but not of the quadratic parameter β, indicating fixation of potentially lethal damage and an intact repair function of sublethal damage. The increase of the α value was also observed in SW1573 cells, but was not accompanied by a significant radiosensitization. A likely explanation for the enhancement of the α value may be an increase in the amount of lethal lesions due to the compacted chromatin structure. Despite the conflicting results of the radiosensitizing effect of AA in the three cell lines tested, the ability of AA to increase the α value suggests potential advantages for clinical application.
View Figures

Figure 1

Figure 2

View References

1 

Joiner M, van der Kogel A and Steel G: Introduction: the significance of radiobiology and radiotherapy for cancer treatment. Basic Clinical Radiobiology. 4th edition. Joiner and van der Kogel A: University Press/Hodder; Arnold, Oxford: pp. 1–10. 2009, View Article : Google Scholar

2 

Haveman J, Castro Kreder N, Rodermond HM, Franken NA, Stalpers LJ, Zdzienicka MZ and Peters GJ: Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil. Oncol Rep. 12:187–192. 2004.PubMed/NCBI

3 

Bergs JWJ, Franken NA, ten Cate R, van Bree C and Haveman J: Effect of cisplatin and gamma irradiation on cell survival, the induction of chromosomal aberrations and apoptosis in SW-1573 cells. Mutat Res. 594:148–154. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Bergs JWJ, Franken NA, Haveman J, Geijsen ED, Crezee J and van Bree C: Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia. 23:329–341. 2007. View Article : Google Scholar

5 

Franken NA, van Bree C, Kipp JBA and Barendsen GW: Modification of potentially lethal damage in irradiated Chinese hamster V79 cells after incorporation of halogenated pyrimidines. Int J Radiat Biol. 72:101–109. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Franken NA, van Bree C, Veltmaat MAT, Rodermond HM, Haveman J and Barendsen GW: Radiosensitization by bromodeoxyuridine and hyperthermia: Analysis of linear and quadratic parameters of radiation survival curves of two human tumor cell lines. J Radiat Res. 42:179–190. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Iliakes G, Pantelias and Okayasu R: Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing. Radiat Res. 119:286–304. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Franken NA, van Bree C, Veltmaat MA, Ludwików G, Kipp JB and Barendsen GW: Increased chromosome exchange frequencies in iodo-deoxyuridine-sensitized human SW-1573 cells after γ-irradiation. Oncol Rep. 6:59–63. 1999.PubMed/NCBI

9 

Squatrito M, Gorrini C and Amati B: Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends Cell Biol. 16:433–442. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Luger K, Mäder AW, Richmond RK, Sargent DF and Richmond TJ: Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature. 389:251–260. 1997.

11 

Kouzarides Tony: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Shahbazian MD and Grunstein M: Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem. 76:75–100. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Kristensen LS, Nielsen HM and Hansen LL: Epigenetics and cancer treatment. Eur J Pharmacol. 625:131–142. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lee KK and Workman JL: Histone acetyltransferase complexes: one size doesn’t fit all. Nat Rev Mol Cell Biol. 8:284–295. 2007.PubMed/NCBI

15 

Dekker FJ and Haisma HJ: Histone acetyl transferases as emerging drug targets. Drug Discov Today. 14:942–948. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Balasubramanyam K, Swaminathan V, Ranganathan A and Kundu TK: Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 278:19134–19140. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Sun Y, Jiang X, Chen S and Price BD: Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 580:4353–4356. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Sun Y, Jiang X, Chen S, Fernandes N and Price BD: A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci. 102:13182–13187. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J and Nakatani Y: Involvement of the Tip60 histone acetylase complex in DNA repair and apoptosis. Cell. 102:463–473. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Goodarzi AA, Noon AT and Jeggo PA: The impact of heterochromatin on DSB repair. Biochem Soc Trans. 37:569–576. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Biade S, Stobbe CC, Boyd JT and Chapman JD: Chemical agents that promote chromatin compaction radiosensitize tumour cells. Int J Radiat Biol. 77:1033–1042. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Franken NA, Rodermond HR, Stap J, Haveman J and van Bree C: Clonogenic assay of cells in vitro. Nat Protoc. 1:2315–2319. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Barendsen GW: Parameters of linear-quadratic radiation dose-effect relationships: dependence on LET and mechanisms of reproductive cell death. Int J Radiat Biol. 71:649–655. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Barendsen GW, van Bree C and Franken NA: Importance of cell proliferative state and potentially lethal damage repair on radiation effectiveness: implications for combined tumor treatments. Int J Oncol. 19:247–256. 2001.

25 

Song S, McCann KE and Brown JM: Radiosensitization of yeast cells by inhibition of histone H4 acetylation. Radiat Res. 170:618–627. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Bandyopadhyay K, Banères JL, Martin A, Blonski C, Parello J and Gjerset RA: Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization. Cell Cycle. 8:2779–2788. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
ten Cate R, Krawczyk P, Stap J, Aten JA and Franken NA: Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines . Oncol Lett 1: 765-769, 2010.
APA
ten Cate, R., Krawczyk, P., Stap, J., Aten, J.A., & Franken, N.A. (2010). Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines . Oncology Letters, 1, 765-769. https://doi.org/10.3892/ol_00000134
MLA
ten Cate, R., Krawczyk, P., Stap, J., Aten, J. A., Franken, N. A."Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines ". Oncology Letters 1.4 (2010): 765-769.
Chicago
ten Cate, R., Krawczyk, P., Stap, J., Aten, J. A., Franken, N. A."Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines ". Oncology Letters 1, no. 4 (2010): 765-769. https://doi.org/10.3892/ol_00000134
Copy and paste a formatted citation
x
Spandidos Publications style
ten Cate R, Krawczyk P, Stap J, Aten JA and Franken NA: Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines . Oncol Lett 1: 765-769, 2010.
APA
ten Cate, R., Krawczyk, P., Stap, J., Aten, J.A., & Franken, N.A. (2010). Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines . Oncology Letters, 1, 765-769. https://doi.org/10.3892/ol_00000134
MLA
ten Cate, R., Krawczyk, P., Stap, J., Aten, J. A., Franken, N. A."Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines ". Oncology Letters 1.4 (2010): 765-769.
Chicago
ten Cate, R., Krawczyk, P., Stap, J., Aten, J. A., Franken, N. A."Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines ". Oncology Letters 1, no. 4 (2010): 765-769. https://doi.org/10.3892/ol_00000134
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team