[Gd@C82(OH)22]n nanoparticles inhibit the migration and adhesion of glioblastoma cells

Wang,Jing; Gu,Feng; Ding,Ting; Liu,Xiaoli; Xing,Gengmei; Zhao,Yuliang; Zhang,Ning; Ma,Yongjie

doi:10.3892/ol_00000135

July-August 2010 Volume 1 Issue 4

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July-August 2010 Volume 1 Issue 4

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Article

[Gd@C82(OH)22]n nanoparticles inhibit the migration and adhesion of glioblastoma cells

Authors:
- Jing Wang
- Feng Gu
- Ting Ding
- Xiaoli Liu
- Gengmei Xing
- Yuliang Zhao
- Ning Zhang
- Yongjie Ma
View Affiliations / Copyright

Affiliations: Central Laboratory of the Oncology Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China
Pages: 771-775
|
Published online on: July 1, 2010

https://doi.org/10.3892/ol_00000135
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Abstract

In our previous study, [Gd@C82(OH)22]n, a fullerene-based nanoparticle, exhibited potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity. The mechanism involved in the anti-tumor effect exerted by [Gd@C82(OH)22]n remains to be elucidated. This study found that glioblastoma cells treated with [Gd@C82(OH)22]n nanoparticles showed a significant impairment in migration and adhesion by cell chemotaxis, scratch and adhesion assays in vitro. Furthermore, our data showed that the key proteins, CD40 and ICAM-1, were involved in the inhibition of adhesion in the [Gd@C82(OH)22]n nanoparticle-treated glioblastoma cells. Thus, our study suggests that the [Gd@C82(OH)22]n nanoparticle is a new potential anti-tumor effector and a therapeutic component for malignant glioblastoma infiltration.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Gd@C82(OH)22]n nanoparticles inhibit the migration and adhesion of glioblastoma cells

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