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Article

A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis

  • Authors:
    • Walid Al Achkar
    • Abdulsamad Wafa
    • Hasmik Mkrtchyan
    • Faten Moassass
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission of Syria, Damascus, Syria. ascientific@aec.org.sy
  • Pages: 801-804
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ol_00000140
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Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Approximately 84% of cases of ALL are classified as B-precursor ALL, 14% of cases are T-cell and 2% of cases are B-cell (B-)ALL. About one third of B-ALL cases show an abnormal karyotype. Combining data obtained by immunophenotyping, karyotyping and molecular cytogenetic analyses allows for a better understanding of this heterogeneous disease. This study reports an exceptional B-ALL case with a poor prognosis and unique complex chromosomal aberrations not previously observed, i.e., a translocation involving the six chromosomal regions 1q42, 4q21, 4q24, 4q35 (twice), 8q22 and 10p15.3 besides 9q34 and 22q11.2.
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Copy and paste a formatted citation
Spandidos Publications style
Al Achkar W, Wafa A, Mkrtchyan H, Moassass F and Liehr T: A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis . Oncol Lett 1: 801-804, 2010.
APA
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., & Liehr, T. (2010). A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis . Oncology Letters, 1, 801-804. https://doi.org/10.3892/ol_00000140
MLA
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., Liehr, T."A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis ". Oncology Letters 1.5 (2010): 801-804.
Chicago
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., Liehr, T."A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis ". Oncology Letters 1, no. 5 (2010): 801-804. https://doi.org/10.3892/ol_00000140
Copy and paste a formatted citation
x
Spandidos Publications style
Al Achkar W, Wafa A, Mkrtchyan H, Moassass F and Liehr T: A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis . Oncol Lett 1: 801-804, 2010.
APA
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., & Liehr, T. (2010). A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis . Oncology Letters, 1, 801-804. https://doi.org/10.3892/ol_00000140
MLA
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., Liehr, T."A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis ". Oncology Letters 1.5 (2010): 801-804.
Chicago
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., Liehr, T."A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis ". Oncology Letters 1, no. 5 (2010): 801-804. https://doi.org/10.3892/ol_00000140
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