Usefulness of 18F-FDG positron emission tomography/computed tomography for the diagnosis of pyothorax-associated lymphoma: A report of three cases

Abe,Yoshiyuki; Tamura,Katsumi; Sakata,Ikuko; Ishida,Jiro; Fukuba,Isao; Matsuoka,Rokuro; Shimizu,Seiichiro; Murakami,Hiroshi; Machida,Kikuo

doi:10.3892/ol_00000146

September-October 2010 Volume 1 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-October 2010 Volume 1 Issue 5

Full Size Image

Article

Usefulness of 18F-FDG positron emission tomography/computed tomography for the diagnosis of pyothorax-associated lymphoma: A report of three cases

Authors:
- Yoshiyuki Abe
- Katsumi Tamura
- Ikuko Sakata
- Jiro Ishida
- Isao Fukuba
- Rokuro Matsuoka
- Seiichiro Shimizu
- Hiroshi Murakami
- Kikuo Machida
View Affiliations / Copyright

Affiliations: Tokorozawa PET Diagnostic Imaging Clinic, Tokorozawa, Saitama 359-1124, Japan. abe@toko-pet.or.jp
Pages: 833-836
|
Published online on: September 1, 2010

https://doi.org/10.3892/ol_00000146
Expand metrics +

Abstract

Pyothorax-associated lymphoma (PAL) is a unique and rare non-Hodgkin's lymphoma developing in the pleural cavity following a long-standing history of chronic pyothorax (CP). The development of F-18 2'-deoxy-2fluoro-D-glucose (FDG) positron emission tomography combined with computed tomography (PET/CT) has contributed to the evaluation of lymphoma staging. However, only a few studies describing FDG-PET/CT findings in PAL have been published. This study reported three cases of PAL; all 3 patients had previously undergone artificial collapse therapy for pulmonary tuberculosis. Both the first case (an 84-year-old male) and second case (an 83-year-old male) complained of abdominal pain. An ultrasound scan revealed a mass shadow in the left chest wall without abnormal findings in the abdomen, and the CT and magnetic resonance imaging scans suggested malignant lymphoma of the left chest. FDG-PET/CT imaging showed extremely intense FDG uptake only in the left pleura and chest wall. Diagnosis was CP in the two patients, showing a high maximum standardized uptake value (SUVmax: early, 14.8 and delayed, 19.4 in the first case; early, 20.8 and delayed, 27.3 in the second case, respectively). Histopathological analysis of the specimens obtained by biopsy of the PET/CT-positive pleural mass showed non-Hodgkin's, diffuse large B cell lymphoma in the two cases. The third case was a 79-year-old male with relapse after right pleuropneumonectomy for PAL (diffuse large B cell lymphoma) 4 years earlier. PET/CT showed intense FDG uptake (SUVmax: early, 19.9 and delayed, 35.7) in the right pleura and chest wall. Diagnosis was CP, suggesting the recurrence of PAL. Furthermore, abnormal intense FDG uptake was noted in the hilar, mediastinal and supraclavicular lymph nodes, as well as in the spleen. In conclusion, FDG-PET/CT imaging is useful in the evaluation of the area of invasion in PAL.

View Figures

View References

1	Nakatsuka S, Yao M, Hoshida Y, Yamamoto S, Iuchi K and Aozasa K: Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol. 20:4255–4260. 2002. View Article : Google Scholar : PubMed/NCBI
2	Aozasa K: Pyothorax-associated lymphoma. J Clin Exp Hematop. 46:5–10. 2006. View Article : Google Scholar
3	Takakuwa T, Ham MF, Luo WJ, Nakatsuka S, Daibata M and Aozasa K: Loss of expression of Epstein-Barr virus nuclear antigen-2 correlates with a poor prognosis in cases of pyothorax-associated lymphoma. Int J Cancer. 118:2782–2789. 2006. View Article : Google Scholar : PubMed/NCBI
4	Ueda T, Andreas C, Itami J, Miyakawa K, Fujimoto H, Ito H and Roos JE: Pyothorax-associated lymphoma: imaging findings. AJR Am J Roentgenol. 194:76–84. 2010. View Article : Google Scholar : PubMed/NCBI
5	Weiler-Sagie M, Bushelev O, Epelbaum R, Dann EJ, Haim N, Avivi I, Ben-Barak A, Ben-Arie Y, Bar-Shalom R and Israel O: (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 51:25–30. 2010. View Article : Google Scholar : PubMed/NCBI
6	Cronin CG, Swords R, Truong MT, Viswanathan C, Rohren E, Giles FJ, O'Dwyer M and Bruzzi JF: Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol. 194:W91–W103. 2010. View Article : Google Scholar : PubMed/NCBI
7	Asakura H, Togami T, Mitani M, Takashima H, Yokoe K, Yamamoto Y, Nishiyama Y, Monden T, Toyama Y and Ohkawa M: Usefulness of FDG-PET imaging for the radiotherapy treatment planning of pyothorax-associated lymphoma. Ann Nucl Med. 19:725–728. 2005. View Article : Google Scholar : PubMed/NCBI
8	Ueda S, Tsuda H, Asakawa H, Shigekawa T, Fukatsu K, Kondo N, Yamamoto M, Hama Y, Tamura K, Ishida J, Abe Y and Mochizuki H: Clinicopathological and prognostic relevance of uptake level using ¹⁸F-fluorodeoxyglucose positron emission tomography computed tomography fusion imaging (¹⁸F-FDG PET/CT) in primary breast cancer. Jpn J Clin Oncol. 38:250–258. 2008.PubMed/NCBI
9	Abe Y, Tamura K, Sakata I, Ishida J, Mukai M, Ohtaki M, Nakamura M and Machida K: Unique intense uptake demonstrated by ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) in primary pancreatic lymphoma: A case report. Oncol Lett. 4:605–607. 2010.PubMed/NCBI
10	Fujimoto M, Haga H, Okamoto M, Obara E, Ishihara M, Mizuta N, Nishimura K and Manabe T: EBV-associated diffuse large B-cell lymphoma arising in the chest wall with surgical mesh implant. Pathol Int. 58:668–671. 2008. View Article : Google Scholar : PubMed/NCBI
11	Santini M, Fiorello A, Vicidomini G, Busiello L and Baldi A: A surgical case of pyothorax-associated lymphoma of T-cell origin arising from the chest wall in chronic empyema. Ann Thorac Surg. 88:642–645. 2009. View Article : Google Scholar : PubMed/NCBI
12	Aruga T, Itami J, Aruga M, Nakajima K, Shibata K, Nojo T, Yasuda S, Uno T, Hara R, Isobe K, Machida N and Ito H: Treatment for pyothorax-associated lymphoma. Radiother Oncol. 56:59–63. 2000. View Article : Google Scholar : PubMed/NCBI
13	Kostakoglu L and Goldsmith SJ: Fluorine-18 fluorodeoxyglucose positron emission tomography in the staging and follow-up of lymphoma: is it time to shift gears? Eur J Nucl Med. 27:1564–1578. 2000. View Article : Google Scholar : PubMed/NCBI
14	Zinzani PL, Fanti S, Battista G, Tani M, Castellucci P, Stefoni V, Alinari L, Farsad M, Musuraca G, Gabriele A, Marchi E, Nanni C, Canini R, Monetti N and Baccarani M: Predictive role of positron emission tomography (PET) in the outcome of lymphoma patients. Br J Cancer. 91:850–854. 2004.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Usefulness of 18F-FDG positron emission tomography/computed tomography for the diagnosis of pyothorax-associated lymphoma: A report of three cases

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles