Effects of photodynamic therapy for superficial esophageal squamous cell carcinoma in vivo and in vitro

Kawazoe,Kaoru; Isomoto,Hajime; Yamaguchi,Naoyuki; Inoue,Naoki; Uehara,Ryohei; Matsushima,Kayoko; Ichikawa,Tatsuki; Takeshima,Fuminao; Nonaka,Takashi; Nanashima,Atsushi; Nagayasu,Takeshi; Uehara,Masataka; Asahina,Izumi; Nakao,Kazuhiko

doi:10.3892/ol_00000155

September-October 2010 Volume 1 Issue 5

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September-October 2010 Volume 1 Issue 5

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Article

Effects of photodynamic therapy for superficial esophageal squamous cell carcinoma in vivo and in vitro

Authors:
- Kaoru Kawazoe
- Hajime Isomoto
- Naoyuki Yamaguchi
- Naoki Inoue
- Ryohei Uehara
- Kayoko Matsushima
- Tatsuki Ichikawa
- Fuminao Takeshima
- Takashi Nonaka
- Atsushi Nanashima
- Takeshi Nagayasu
- Masataka Uehara
- Izumi Asahina
- Kazuhiko Nakao
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
Pages: 877-882
|
Published online on: September 1, 2010

https://doi.org/10.3892/ol_00000155
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Abstract

Photodynamic therapy (PDT) is an ablative treatment leading to intracellular photoexcitation and injury. A total of 15 patients with superficial esophageal squamous cell carcinoma (ESCC) without metastasis underwent PDT and 48-72 h after intravenous Photofrin, the patients were treated with a 630-nm excimer dye laser. A total of 13 patients had local tumor recurrence after definitive chemoradiotherapy (CRT) consisting of 5-fluorouracil (5-FU) and cisplatin (CDDP). Of 6 patients, 5 had submucosal ESCC and were treated with S-1. Complete reponse was achieved by 11 patients with initial PDT, but 2 had recurrences. The recurrent/residual tumors were successfully treated with repeated PDT. Two patients with intramucosal ESCC succumbed due to metastatic disease, but 11 patients were disease-free. The 5 patients treated with S-1 remained alive despite submucosal ESCC. PDT was applied to human ESCC cells in vitro in the presence or absence of 5-FU or CDDP. The combination of PDT with 5-FU or CDDP resulted in enhanced cytotoxic effects, thereby reducing the effective dosage of each drug. PDT is a promising treatment option for selected ESCC cases, particularly for local recurrence following CRT. Our experience suggests that PDT is more effective when combined with chemotherapy.

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1	Cooper JS, Guo MD, Herskovic A, et al: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA. 281:1623–1627. 1999. View Article : Google Scholar : PubMed/NCBI
2	Herskovic A, Martz K, Al-Sarraf M, et al: Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med. 326:1593–1598. 1992. View Article : Google Scholar : PubMed/NCBI
3	Ishikura S, Nihei K, Ohtsu A, et al: Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus. J Clin Oncol. 21:2697–2702. 2003. View Article : Google Scholar : PubMed/NCBI
4	Swisher SG, Wynn P, Putnam JB, et al: Salvage esophagectomy for recurrent tumors after definitive chemotherapy and radiotherapy. J Thorac Cardiovasc Surg. 123:175–183. 2002. View Article : Google Scholar : PubMed/NCBI
5	Hattori S, Muto M, Ohtsu A, et al: EMR as salvage treatment for patients with locoregional failure of definitive chemoradiotherapy for esophageal cancer. Gastrointest Endosc. 58:65–70. 2003. View Article : Google Scholar : PubMed/NCBI
6	Gotoda T, Kondo H, Ono H, et al: A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc. 50:560–563. 1999. View Article : Google Scholar : PubMed/NCBI
7	Isomoto H and Yamaguchi N: Endoscopic submucosal dissection in the era of proton pump inhibitors. J Clin Biochem Nutr. 44:205–211. 2009. View Article : Google Scholar : PubMed/NCBI
8	Fujishiro M, Kodashima S, Goto O, et al: Endoscopic submucosal dissection for esophageal squamous cell neoplasms. Dig Endosc. 21:109–115. 2009. View Article : Google Scholar : PubMed/NCBI
9	Isomoto H, Nishiyama H, Yamaguchi N, et al: Clinicopathological factors associated with clinical outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms. Endoscopy. 41:679–683. 2009. View Article : Google Scholar
10	Wolfsen HC: Uses of photodynamic therapy in premalignant and malignant lesions of the gastrointestinal tract beyond the esophagus. J Clin Gastroenterol. 39:653–664. 2005. View Article : Google Scholar : PubMed/NCBI
11	Robertson CA, Evans DH and Abrahamse H: Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. J Photochem Photobiol B. 96:1–8. 2009. View Article : Google Scholar : PubMed/NCBI
12	Hahn SM, Putt ME, Metz J, et al: Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Clin Cancer Res. 12:5464–5470. 2006. View Article : Google Scholar : PubMed/NCBI
13	Keeley SB, Pennathur A, Gooding W, Landreneau RJ, Christie NA and Luketich J: Photodynamic therapy with curative intent for Barrett's esophagus with high grade dysplasia and superficial esophageal cancer. Ann Surg Oncol. 14:2406–2410. 2007. View Article : Google Scholar
14	Yano T, Muto M, Minashi K, Ohtsu A and Yoshida S: Photodynamic therapy as salvage treatment for local failures after definitive chemoradiotherapy for esophageal cancer. Gastrointest Endosc. 62:31–36. 2005. View Article : Google Scholar : PubMed/NCBI
15	Hayashi I, Morishita Y, Imai K, Nakamura M, Nakachi K and Hayashi T: High-throughput spectrophotometric assay of reactive oxygen species in serum. Mutat Res. 63:55–61. 2007. View Article : Google Scholar : PubMed/NCBI
16	Fujii M, Kochi M and Takayama T: Recent advances in chemotherapy for advanced gastric cancer in Japan. Surg Today. 40:295–300. 2010. View Article : Google Scholar : PubMed/NCBI
17	Nonaka M, Ikeda H and Inokuchi T: Effect of combined photodynamic and chemotherapeutic treatment on lymphoma cells in vitro. Cancer Lett. 184:171–178. 2002. View Article : Google Scholar : PubMed/NCBI
18	Veinot JP and Edwards WD: Pathology of radiation-induced heart disease: a surgical and autopsy study of 27 cases. Hum Pathol. 27:766–773. 1996. View Article : Google Scholar : PubMed/NCBI
19	Ohtsu A, Yoshida S and Saijo N: Disparities in gastric cancer chemotherapy between the East and West. J Clin Oncol. 24:2188–2196. 2006. View Article : Google Scholar : PubMed/NCBI
20	Plaetzer K, Krammer B, Berlanda J, Berr F and Kiesslich T: Photophysics and photochemistry of photodynamic therapy: fundamental aspects. Lasers Med Sci. 24:259–268. 2009. View Article : Google Scholar : PubMed/NCBI
21	Wang J and Yi J: Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol Ther. 7:1875–1884. 2008. View Article : Google Scholar : PubMed/NCBI
22	Park S, Hong SP, Oh TY, Bang S, Chung JB and Song SY: Paclitaxel augments cytotoxic effect of photodynamic therapy using verteporfin in gastric and bile duct cancer cells. Photochem Photobiol Sci. 7:769–774. 2008. View Article : Google Scholar : PubMed/NCBI
23	Zimmermann A, Walt H, Haller U, Baas P and Klein SD: Effects of chlorin-mediated photodynamic therapy combined with fluoropyrimidines in vitro and in a patient. Cancer Chemother Pharmacol. 51:147–154. 2003.PubMed/NCBI
24	Takahira K, Sano M, Arai H and Hanai H: Apoptosis of gastric cancer cell line MKN45 by photodynamic treatment with photofrin. Lasers Med Sci. 19:89–94. 2004. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of photodynamic therapy for superficial esophageal squamous cell carcinoma in vivo and in vitro

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