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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-April 2003 Volume 10 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-April 2003 Volume 10 Issue 2

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Article

The preventive effect of antineoplaston AS2-1 on HCC recurrence

  • Authors:
    • Hideaki Tsuda
    • Michio Sata
    • Tutomu Kumabe
    • Masafumi Uchida
    • Hiroshi Hara

  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Kurume Daiichi Social Insurance Hospital, Kushihara Kurumeshi, Fukuoka 830-0013, Japan
  • Pages: 391-397
    |
    Published online on: March 1, 2003
       https://doi.org/10.3892/or.10.2.391
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Abstract

Once hepatocellular carcinoma (HCC) develops, it repeats intrahepatic metastasis and has multicentric occurrence, which requires frequent treatment. We designed a phase II clinical trail to clarify whether antineoplaston AS2-1, a mixture of sodium salts of phenylacetylglutamine and phenylacetic acid at a ratio of 1:4, prolongs the recurrence-free interval of HCC patients who undergo frequent treatments for recurrence. Ten patients were enrolled in this trial, 2 in stage I, 6 in stage II, 1 in stage III, 1 in stage IV-B at initial diagnosis. Ten patients experienced 35 recurrence-free intervals. Recurrence-free intervals during antineoplaston AS2-1 administration were significantly longer than those without antineoplaston AS2-1 (16.19±15.916 versus 5.05±2.897 months: p<0.01). Patients who experienced recurrence-free intervals with and without antineoplaston AS2-1 showed longer intervals during antineoplaston AS2-1 administration than those before and after antineoplaston AS2-1 administration (14.47±13.821 versus 5.07±2.989 versus 5.02±3.009 months: p<0.05). Two patients in stage I showed longer recurrence-free intervals than those in more advanced stages. In conclusion, antineoplaston AS2-1 could not prevent recurrence of HCC but prolonged the recurrence-free interval between regional treatments and improved survival rate of these patients.

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Copy and paste a formatted citation
Spandidos Publications style
Tsuda H, Sata M, Kumabe T, Uchida M and Hara H: The preventive effect of antineoplaston AS2-1 on HCC recurrence. Oncol Rep 10: 391-397, 2003.
APA
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., & Hara, H. (2003). The preventive effect of antineoplaston AS2-1 on HCC recurrence. Oncology Reports, 10, 391-397. https://doi.org/10.3892/or.10.2.391
MLA
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., Hara, H."The preventive effect of antineoplaston AS2-1 on HCC recurrence". Oncology Reports 10.2 (2003): 391-397.
Chicago
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., Hara, H."The preventive effect of antineoplaston AS2-1 on HCC recurrence". Oncology Reports 10, no. 2 (2003): 391-397. https://doi.org/10.3892/or.10.2.391
Copy and paste a formatted citation
x
Spandidos Publications style
Tsuda H, Sata M, Kumabe T, Uchida M and Hara H: The preventive effect of antineoplaston AS2-1 on HCC recurrence. Oncol Rep 10: 391-397, 2003.
APA
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., & Hara, H. (2003). The preventive effect of antineoplaston AS2-1 on HCC recurrence. Oncology Reports, 10, 391-397. https://doi.org/10.3892/or.10.2.391
MLA
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., Hara, H."The preventive effect of antineoplaston AS2-1 on HCC recurrence". Oncology Reports 10.2 (2003): 391-397.
Chicago
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., Hara, H."The preventive effect of antineoplaston AS2-1 on HCC recurrence". Oncology Reports 10, no. 2 (2003): 391-397. https://doi.org/10.3892/or.10.2.391
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