Anti-angiogenic activity of conjugated linoleic acid on basic fibroblast growth factor-induced angiogenesis

  • Authors:
    • Eun-Joung Moon
    • You Mie Lee
    • Kyu-Won Kim
  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/or.10.3.617
  • Pages: 617-621
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Abstract

Conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. Cancer cells produce various angiogenic factors which stimulate host vascular endothelial cell mitogenesis and chemotaxis for their growth and metastasis. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor that is expressed in many tumors. In this study, we found that CLA decreased bFGF-induced endothelial cell proliferation and DNA synthesis in a dose-dependent manner. However, CLA did not inhibit endothelial cell migration. Furthermore, CLA showed a potent inhibitory effect on embryonic vasculogenesis and bFGF-induced angiogenesis in vivo. Collectively, these results suggest that CLA selectively inhibits the active proliferating endothelial cells induced by bFGF, which may explain its anti-carcinogenic properties in vivo.

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May-June 2003
Volume 10 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Moon E, Lee YM and Kim K: Anti-angiogenic activity of conjugated linoleic acid on basic fibroblast growth factor-induced angiogenesis. Oncol Rep 10: 617-621, 2003.
APA
Moon, E., Lee, Y.M., & Kim, K. (2003). Anti-angiogenic activity of conjugated linoleic acid on basic fibroblast growth factor-induced angiogenesis. Oncology Reports, 10, 617-621. https://doi.org/10.3892/or.10.3.617
MLA
Moon, E., Lee, Y. M., Kim, K."Anti-angiogenic activity of conjugated linoleic acid on basic fibroblast growth factor-induced angiogenesis". Oncology Reports 10.3 (2003): 617-621.
Chicago
Moon, E., Lee, Y. M., Kim, K."Anti-angiogenic activity of conjugated linoleic acid on basic fibroblast growth factor-induced angiogenesis". Oncology Reports 10, no. 3 (2003): 617-621. https://doi.org/10.3892/or.10.3.617