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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2003 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects

  • Authors:
    • Yan-Qing Wang
    • Akihiko Wada
    • Shin-Ichi Ugai
    • Masatoshi Tagawa

  • View Affiliations / Copyright

    Affiliations: Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
  • Pages: 909-913
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/or.10.4.909
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Abstract

We examined whether expression of monokine induced by IFN-γ (Mig, CXCL9) in tumors could produce antitumor effects. Murine lung carcinoma cells (A11) were retrovirally transduced with the murine Mig gene (A11/Mig) and were inoculated into syngeneic mice. Although proliferation in vitro of A11/Mig cells was not different from that of parent cells, the growth in vivo of A11/Mig tumors was significantly retarded compared with that of parent tumors. The antitumor effect was dependent on the amount of Mig produced. We compared the expression level of marker genes of lymphocytes and endothelial cells between parent and A11/Mig tumor masses with reverse transcription-polymerase chain reaction. Expression of CD4, CD8α, CD40, CD86, CD28, CD31 and vascular endothelial growth factor was not different between the two tumor groups but expression of CD40 ligand, CD80, NK1.1 and CXCR3 was relatively lower in A11/Mig tumors. Although Mig is a chemotactic factor for activated T and NK cells and an inhibitor for angiogenesis, the present data suggested that production of Mig in tumors did not recruit activated T and NK cells efficiently or suppress angiogenesis. The antitumor effects by Mig could be independent of anti-angiogenesis and recruitment of T and NK cells.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wada A, Ugai S and Tagawa M: Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects. Oncol Rep 10: 909-913, 2003.
APA
Wang, Y., Wada, A., Ugai, S., & Tagawa, M. (2003). Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects. Oncology Reports, 10, 909-913. https://doi.org/10.3892/or.10.4.909
MLA
Wang, Y., Wada, A., Ugai, S., Tagawa, M."Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects". Oncology Reports 10.4 (2003): 909-913.
Chicago
Wang, Y., Wada, A., Ugai, S., Tagawa, M."Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects". Oncology Reports 10, no. 4 (2003): 909-913. https://doi.org/10.3892/or.10.4.909
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wada A, Ugai S and Tagawa M: Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects. Oncol Rep 10: 909-913, 2003.
APA
Wang, Y., Wada, A., Ugai, S., & Tagawa, M. (2003). Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects. Oncology Reports, 10, 909-913. https://doi.org/10.3892/or.10.4.909
MLA
Wang, Y., Wada, A., Ugai, S., Tagawa, M."Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects". Oncology Reports 10.4 (2003): 909-913.
Chicago
Wang, Y., Wada, A., Ugai, S., Tagawa, M."Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects". Oncology Reports 10, no. 4 (2003): 909-913. https://doi.org/10.3892/or.10.4.909
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