Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells
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- Published online on: July 1, 2003 https://doi.org/10.3892/or.10.4.979
- Pages: 979-984
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Abstract
We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-α2a, interferon-α2b and interferon-α2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-α2a interferon-α2b or interferon-α2c had no synergistic or additive effect compared to each drug singly.
