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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors

  • Authors:
    • Satoru Tokuyama
    • Seiichi Saito
    • Toshiko Takahashi
    • Chikara Ohyama
    • Akihiro Ito
    • Satoru Kanto
    • Makoto Satoh
    • Senji Hoshi
    • Mareyuki Endoh
    • Yoichi Arai

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tohoku University School of Medicine, Sendai, Japan
  • Pages: 1097-1104
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1097
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Abstract

Stage-specific embryonic antigen-4 (SSEA-4) is expressed in testicular germ-cell tumors (GCT) according to studies using thin-layer chromatography (TLC) immunostaining. To further understand the relationship between SSEA-4 and the histogenesis of testicular GCT, we examined the expression of SSEA-4 in 43 samples of testicular GCT either by immunohistochemical staining or by TLC immunostaining. Immunohistochemical staining detected SSEA-4 in spermatogonia from the non-tumor parts of the testis and in all of 8 samples of intratubular germ cell neoplasia unclassified (IGCNU). Immunohistochemical staining was SSEA-4 positive in all 9 seminomas, and in one yolk sac tumor and in 5 embryonal carcinomas among 9 non-seminomas. Immunostaining with TLC showed that SSEA-4 was retained in 15 of 16 seminomas and in 4 of 8 non-seminomas. These results demonstrate an antigenic link between spermatogonia, IGCNU, and testicular GCT. We suggest that SSEA-4 is associated with the histogenesis of testicular GCT.

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Copy and paste a formatted citation
Spandidos Publications style
Tokuyama S, Saito S, Takahashi T, Ohyama C, Ito A, Kanto S, Satoh M, Hoshi S, Endoh M, Arai Y, Arai Y, et al: Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. Oncol Rep 10: 1097-1104, 2003.
APA
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S. ... Arai, Y. (2003). Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. Oncology Reports, 10, 1097-1104. https://doi.org/10.3892/or.10.5.1097
MLA
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S., Satoh, M., Hoshi, S., Endoh, M., Arai, Y."Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors". Oncology Reports 10.5 (2003): 1097-1104.
Chicago
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S., Satoh, M., Hoshi, S., Endoh, M., Arai, Y."Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors". Oncology Reports 10, no. 5 (2003): 1097-1104. https://doi.org/10.3892/or.10.5.1097
Copy and paste a formatted citation
x
Spandidos Publications style
Tokuyama S, Saito S, Takahashi T, Ohyama C, Ito A, Kanto S, Satoh M, Hoshi S, Endoh M, Arai Y, Arai Y, et al: Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. Oncol Rep 10: 1097-1104, 2003.
APA
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S. ... Arai, Y. (2003). Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. Oncology Reports, 10, 1097-1104. https://doi.org/10.3892/or.10.5.1097
MLA
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S., Satoh, M., Hoshi, S., Endoh, M., Arai, Y."Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors". Oncology Reports 10.5 (2003): 1097-1104.
Chicago
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S., Satoh, M., Hoshi, S., Endoh, M., Arai, Y."Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors". Oncology Reports 10, no. 5 (2003): 1097-1104. https://doi.org/10.3892/or.10.5.1097
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