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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells

  • Authors:
    • Hiroshi Okano
    • Katsuya Shiraki
    • Hidekazu Inoue
    • Tomoyuki Kawakita
    • Yukiko Saitou
    • Naoyuki Enokimura
    • Norihiko Yamamoto
    • Kazushi Sugimoto
    • Kazumoto Murata
    • Takeshi Nakano

  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Mie University School of Medicine, Mie 514-8507, Japan
  • Pages: 1145-1148
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1145
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Abstract

The TNF-receptor family has a dual signaling pathway, including induction of apoptosis and NF-κB activation associated with cell survival. Hepatocellular carcinoma (HCC) cells express TNF-receptor family members and the signaling from these receptors induces NF-κB activation. However, the role of Fas in induction of NF-κB activation in HCC cells is not well understood. In this study, SK-Hep1, HepG2 or HLE cells were stimulated by anti-Fas agonistic antibody. Fas stimulation induced NF-κB activation in a dose-dependent manner in SK-Hep1 and HepG2 cell lines, but not in HLE cells. Anti-Fas agonistic antibody or the metabolic inhibitor, cyclo-heximide (CHX), failed to kill SK-Hep1 cells, but co-incubation with anti-Fas agonistic antibody and CHX was effective for induction of apoptosis. SK-Hep1 cell lines receiving Fas stimulation had increased viability, but the extent of cell proliferation was not dose-dependent. The observation suggests that Fas stimulation may contribute to HCC cell survival or proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Okano H, Shiraki K, Inoue H, Kawakita T, Saitou Y, Enokimura N, Yamamoto N, Sugimoto K, Murata K, Nakano T, Nakano T, et al: Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells. Oncol Rep 10: 1145-1148, 2003.
APA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Saitou, Y., Enokimura, N. ... Nakano, T. (2003). Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells. Oncology Reports, 10, 1145-1148. https://doi.org/10.3892/or.10.5.1145
MLA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Saitou, Y., Enokimura, N., Yamamoto, N., Sugimoto, K., Murata, K., Nakano, T."Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells". Oncology Reports 10.5 (2003): 1145-1148.
Chicago
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Saitou, Y., Enokimura, N., Yamamoto, N., Sugimoto, K., Murata, K., Nakano, T."Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells". Oncology Reports 10, no. 5 (2003): 1145-1148. https://doi.org/10.3892/or.10.5.1145
Copy and paste a formatted citation
x
Spandidos Publications style
Okano H, Shiraki K, Inoue H, Kawakita T, Saitou Y, Enokimura N, Yamamoto N, Sugimoto K, Murata K, Nakano T, Nakano T, et al: Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells. Oncol Rep 10: 1145-1148, 2003.
APA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Saitou, Y., Enokimura, N. ... Nakano, T. (2003). Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells. Oncology Reports, 10, 1145-1148. https://doi.org/10.3892/or.10.5.1145
MLA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Saitou, Y., Enokimura, N., Yamamoto, N., Sugimoto, K., Murata, K., Nakano, T."Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells". Oncology Reports 10.5 (2003): 1145-1148.
Chicago
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Saitou, Y., Enokimura, N., Yamamoto, N., Sugimoto, K., Murata, K., Nakano, T."Fas stimulation activates NF-κB in SK-Hep1 hepatocellular carcinoma cells". Oncology Reports 10, no. 5 (2003): 1145-1148. https://doi.org/10.3892/or.10.5.1145
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