Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus

  • Authors:
    • Tsuyoshi Noguchi
    • Shinsuke Wada
    • Shinsuke Takeno
    • Hatsuo Moriyama
    • Yasuhiko Kimura
    • Yuzo Uchida
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1161
  • Pages: 1161-1164
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Abstract

Macrophages have been reported to play an important role in suppressing tumor growth, and heat shock protein 70 (HSP70) in presenting tumor specific antigens. The objective of the present study was to investigate the relationship between lymph node metastasis and these two molecular biological markers in superficial esophageal carcinoma. Subjects were 37 patients with untreated submucosal esophageal carcinoma who underwent curative surgery. Among these patients, expression of CD68-positive macrophages in the tumor stroma and expression of HSP70 in tumor cells were analyzed. The results demonstrated that expression of CD68-positive macrophages was significantly greater among patients without lymph node metastasis (p<0.0001), and a significant correlation existed between HSP70 expression and CD68 expression (p=0.0125). In superficial esophageal carcinoma, lymph node metastasis is correlated with expression of CD68-positive macrophages in tumor stroma and expression of HSP70 in tumor cells. These two markers may therefore prove useful for therapy planning.

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September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Noguchi T, Wada S, Takeno S, Moriyama H, Kimura Y and Uchida Y: Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus. Oncol Rep 10: 1161-1164, 2003.
APA
Noguchi, T., Wada, S., Takeno, S., Moriyama, H., Kimura, Y., & Uchida, Y. (2003). Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus. Oncology Reports, 10, 1161-1164. https://doi.org/10.3892/or.10.5.1161
MLA
Noguchi, T., Wada, S., Takeno, S., Moriyama, H., Kimura, Y., Uchida, Y."Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus". Oncology Reports 10.5 (2003): 1161-1164.
Chicago
Noguchi, T., Wada, S., Takeno, S., Moriyama, H., Kimura, Y., Uchida, Y."Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus". Oncology Reports 10, no. 5 (2003): 1161-1164. https://doi.org/10.3892/or.10.5.1161