The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy

Ranieri,Girolamo; Passantino,Letizia; Patruno,Rosa; Passantino,Giuseppe; Jirillo,Felicita; Catino,Annamaria; Mattioli,Vittorio; Gadaleta,Cosmo; Ribatti,Domenico

doi:10.3892/or.10.5.1189

September-October 2003 Volume 10 Issue 5

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September-October 2003 Volume 10 Issue 5

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Article

The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy

Authors:
- Girolamo Ranieri
- Letizia Passantino
- Rosa Patruno
- Giuseppe Passantino
- Felicita Jirillo
- Annamaria Catino
- Vittorio Mattioli
- Cosmo Gadaleta
- Domenico Ribatti
View Affiliations / Copyright

Affiliations: National Cancer Institute, Interventional Radiology Unit, Bari 70126, Italy. giroran@tiscalinet.it
Pages: 1189-1193
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Published online on: September 1, 2003

https://doi.org/10.3892/or.10.5.1189
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Abstract

Substantial experimental data suggest that tumour progression is associated with angiogenesis and that increase in microvessel density (MVD) is associated with increase in mast cells density (MCD). Dog mast cell tumour (MCT) is common in dog with an incidence much higher than that found in human and in both species several common biological and clinical characteristics have been demonstrated. To evaluate the role of angiogenesis in progression of this tumour and to correlate MVD and MCD, in this study a series of 78 MCT was investigated. Serial sections obtained from biopsy specimens were processed with toluidine blue staining, specific for MC identification, and by immunohistochemistry using a polyclonal antibody anti factor VIII-related antigen (FVIII-RA), used as an endothelial marker, and MVD and MCD were determined. Results showed that MVD was significantly higher in poorly differentiated (G3) MCTs than in intermediate (G2) and well differentiated (G1) MCTs and that MCD and MVD were significantly correlated in G3, but not in G1 and G2 subgroups. These data indicate that angiogenesis and MCD are significantly correlated in MCTs progression.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy

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