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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor

  • Authors:
    • Akiko Yokoi
    • Kimberly W. McCrudden
    • Jianzhong Huang
    • Eugene S. Kim
    • Samuel Z. Soffer
    • Jason S. Frischer
    • Anna Serur
    • Tamara New
    • Jenny Yuan
    • Mahesh Mansukhani
    • Kathleen O'Toole
    • Darrell J. Yamashiro
    • Jessica J. Kandel
  • View Affiliations / Copyright

    Affiliations: Division of Pediatric Surgery, Columbia University, New York, NY, USA
  • Pages: 1271-1274
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1271
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Abstract

Her2/neu regulates angiogenesis in human breast cancer, in part by stabilizing hypoxia-inducible factor 1α (HIF-1α), causing accumulation of the HIF-1 heterodimer and thus increasing expression of the proangiogenic cytokine VEGF. Her2/neu has recently been shown to be overexpressed in a subset of Wilms tumors. Using her2/neu (+) and her2/neu (−) Wilms tumor cell lines, we tested the effect of blocking anti-her2/neu antibody in vitro and in vivo. Blocking antibody did not alter VEGF expression in vitro, but decreased expression of VEGF in her2/neu (+) Wilms tumor xenografts. Tumor suppression was less marked than in parallel experiments using agents directly blocking VEGF. HIF-1α immunostaining was not altered in her2/neu (+) xenografts exposed to blocking antibody. These results suggest that her2/neu contributes to Wilms tumor angiogenesis in vivo by regulating VEGF, but other processes may act to rescue HIF-1α and thus to support tumor growth in this system.

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Copy and paste a formatted citation
Spandidos Publications style
Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, Mansukhani M, et al: Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncol Rep 10: 1271-1274, 2003.
APA
Yokoi, A., McCrudden, K.W., Huang, J., Kim, E.S., Soffer, S.Z., Frischer, J.S. ... Kandel, J.J. (2003). Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncology Reports, 10, 1271-1274. https://doi.org/10.3892/or.10.5.1271
MLA
Yokoi, A., McCrudden, K. W., Huang, J., Kim, E. S., Soffer, S. Z., Frischer, J. S., Serur, A., New, T., Yuan, J., Mansukhani, M., O'Toole, K., Yamashiro, D. J., Kandel, J. J."Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor". Oncology Reports 10.5 (2003): 1271-1274.
Chicago
Yokoi, A., McCrudden, K. W., Huang, J., Kim, E. S., Soffer, S. Z., Frischer, J. S., Serur, A., New, T., Yuan, J., Mansukhani, M., O'Toole, K., Yamashiro, D. J., Kandel, J. J."Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor". Oncology Reports 10, no. 5 (2003): 1271-1274. https://doi.org/10.3892/or.10.5.1271
Copy and paste a formatted citation
x
Spandidos Publications style
Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, Mansukhani M, et al: Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncol Rep 10: 1271-1274, 2003.
APA
Yokoi, A., McCrudden, K.W., Huang, J., Kim, E.S., Soffer, S.Z., Frischer, J.S. ... Kandel, J.J. (2003). Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncology Reports, 10, 1271-1274. https://doi.org/10.3892/or.10.5.1271
MLA
Yokoi, A., McCrudden, K. W., Huang, J., Kim, E. S., Soffer, S. Z., Frischer, J. S., Serur, A., New, T., Yuan, J., Mansukhani, M., O'Toole, K., Yamashiro, D. J., Kandel, J. J."Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor". Oncology Reports 10.5 (2003): 1271-1274.
Chicago
Yokoi, A., McCrudden, K. W., Huang, J., Kim, E. S., Soffer, S. Z., Frischer, J. S., Serur, A., New, T., Yuan, J., Mansukhani, M., O'Toole, K., Yamashiro, D. J., Kandel, J. J."Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor". Oncology Reports 10, no. 5 (2003): 1271-1274. https://doi.org/10.3892/or.10.5.1271
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