Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma

  • Authors:
    • Yasuhiro Ito
    • Hiroshi Yoshida
    • Takashi Uruno
    • Keiichi Nakano
    • Akihiro Miya
    • Kaoru Kobayashi
    • Tamotsu Yokozawa
    • Fumio Matsuzuka
    • Nariaki Matsuura
    • Kennichi Kakudo
    • Kanji Kuma
    • Akira Miyauchi
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1337
  • Pages: 1337-1340
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Abstract

Survivin is a novel member of the apoptosis protein inhibitors, but according to previous reports, it is also significantly linked to cell proliferating activity. In this study, we investigated the expression of survivin in thyroid neoplasms. Survivin was only occasionally expressed in normal follicular cells, whereas in follicular and papillary carcinomas, about 20% of cases were positive for survivin. The incidence was significantly higher in advanced stage papillary carcinoma (p=0.0080) and papillary and follicular carcinomas with poorly differentiated lesions (p=0.0150). In anaplastic carcinoma, survivin positivity was observed in 84% of the cases, which was in significantly higher incidence than in papillary or follicular carcinoma (p<0.0001). These results suggest that survivin is strongly related to the dedifferentiation of thyroid carcinoma.

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September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ito Y, Yoshida H, Uruno T, Nakano K, Miya A, Kobayashi K, Yokozawa T, Matsuzuka F, Matsuura N, Kakudo K, Kakudo K, et al: Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma. Oncol Rep 10: 1337-1340, 2003.
APA
Ito, Y., Yoshida, H., Uruno, T., Nakano, K., Miya, A., Kobayashi, K. ... Miyauchi, A. (2003). Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma. Oncology Reports, 10, 1337-1340. https://doi.org/10.3892/or.10.5.1337
MLA
Ito, Y., Yoshida, H., Uruno, T., Nakano, K., Miya, A., Kobayashi, K., Yokozawa, T., Matsuzuka, F., Matsuura, N., Kakudo, K., Kuma, K., Miyauchi, A."Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma". Oncology Reports 10.5 (2003): 1337-1340.
Chicago
Ito, Y., Yoshida, H., Uruno, T., Nakano, K., Miya, A., Kobayashi, K., Yokozawa, T., Matsuzuka, F., Matsuura, N., Kakudo, K., Kuma, K., Miyauchi, A."Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma". Oncology Reports 10, no. 5 (2003): 1337-1340. https://doi.org/10.3892/or.10.5.1337