Protracted administration of weekly docetaxel in metastatic breast cancer

Kuroi,Katsumasa; Bando,Hiroko; Saji,Shigehira; Toi,Masakazu

doi:10.3892/or.10.5.1479

September-October 2003 Volume 10 Issue 5

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September-October 2003 Volume 10 Issue 5

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Article

Protracted administration of weekly docetaxel in metastatic breast cancer

Authors:
- Katsumasa Kuroi
- Hiroko Bando
- Shigehira Saji
- Masakazu Toi
View Affiliations / Copyright

Affiliations: Department of Surgery, Showa University Toyosu Hospital, Tokyo 135-8577, Japan. kurochan@dd.iij4u.or.jp
Pages: 1479-1484
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Published online on: September 1, 2003

https://doi.org/10.3892/or.10.5.1479
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Abstract

The purpose of this study was to evaluate the efficacy and toxicity of weekly docetaxel in metastatic breast cancer. Fifty-seven patients were enrolled in this study of weekly docetaxel given at 25 mg/m2/week as a 1-h infusion in out-patient setting. Each cycle consisted of 3 weeks of therapy followed by 1-week treatment break, and the patients received a median of 24 infusions with a median cumulative dose of 600 mg/m2. Overall response rate was 30% [95% confidence interval (CI), 18-42%], and 31% (18-42%) of patients had stable disease for at least 6 months. With a median follow-up of 16 months, the median time to treatment failure was 11 months (6-14 M), and 3-year survival rate was 60%. There was no grade 4 toxicity, and myelosuppression, fatigue, nausea, vomiting was mild, thus the regimen was generally well tolerated. On the other hand, 44% of patients had grade 1-2 nail change, 21% had grade 3 pleural effusion, 17% had grade 1-2 tearing, and these became more common with prolonged administration of docetaxel. Thus, a weekly schedule of docetaxel at low dose maintains activity and is less myelosuppressive, however, one should be careful about cumulative toxicities.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Protracted administration of weekly docetaxel in metastatic breast cancer

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Abstract

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