Mutational analysis of ras gene family in lung cancer in Thai
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- Published online on: September 1, 2003 https://doi.org/10.3892/or.10.5.1497
- Pages: 1497-1501
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Abstract
H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G↷T transversion (62%), G↷A transition (15%) and G↷C transition (15%), whereas T↷G transversion and A↷G transition were detected in N-ras mutant gene.
