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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival

  • Authors:
    • Estrid V.S. Høgdall
    • Julia S. Johansen
    • Susanne K. Kjaer
    • Paul A. Price
    • Lise Christensen
    • Jan Blaakaer
    • Johannes E. Bock
    • Eva Glud
    • Claus K. Høgdall

  • View Affiliations / Copyright

    Affiliations: Institute of Cancer Epidemiology, Danish Cancer Society, DK-2100 Copenhagen Ø, Denmark. hogdall@dadlnet.dk
  • Pages: 1535-1538
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1535
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Abstract

YKL-40 (human cartilage glycoprotein-39) is a member of family 18 glycosyl hydrolases. YKL-40 is a growth factor and is secreted by cancer cells. High serum levels of YKL-40 in patients with colorectal cancer and recurrent metastatic breast cancer have been associated with a poor prognosis. We evaluated the prognostic value of plasma YKL-40 in patients with primary ovarian cancer (OC). YKL-40 was determined by ELISA in plasma obtained preoperatively from 47 women with stage III OC and in plasma from 79 healthy females. The results showed that plasma YKL-40 was elevated compared to healthy females in 57% of the OC patients and was highest in the patients who died during the follow-up compared to the patients still alive (186 vs. 78 µg/l, p=0.002). Patients with high plasma YKL-40 (>130 µg/l) had significantly (p=0.0003) shorter survival than patients with normal plasma YKL-40. Multivariate Cox regression analysis showed that plasma YKL-40 (RH=3.95; 95% CI, 1.52-10.27; p=0.005) and radicality after primary surgery (RH=4.03; 95% CI, 1.81-8.97; p=0.001) were independent prognostic factors of survival, whereas age, histological type of tumour and serum CA125 had no independent prognostic value. In conclusion, plasma levels of YKL-40 proved of prognostic value in stage III OC patients.

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Copy and paste a formatted citation
Spandidos Publications style
Høgdall EV, Johansen JS, Kjaer SK, Price PA, Christensen L, Blaakaer J, Bock JE, Glud E and Høgdall CK: High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncol Rep 10: 1535-1538, 2003.
APA
Høgdall, E.V., Johansen, J.S., Kjaer, S.K., Price, P.A., Christensen, L., Blaakaer, J. ... Høgdall, C.K. (2003). High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncology Reports, 10, 1535-1538. https://doi.org/10.3892/or.10.5.1535
MLA
Høgdall, E. V., Johansen, J. S., Kjaer, S. K., Price, P. A., Christensen, L., Blaakaer, J., Bock, J. E., Glud, E., Høgdall, C. K."High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival". Oncology Reports 10.5 (2003): 1535-1538.
Chicago
Høgdall, E. V., Johansen, J. S., Kjaer, S. K., Price, P. A., Christensen, L., Blaakaer, J., Bock, J. E., Glud, E., Høgdall, C. K."High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival". Oncology Reports 10, no. 5 (2003): 1535-1538. https://doi.org/10.3892/or.10.5.1535
Copy and paste a formatted citation
x
Spandidos Publications style
Høgdall EV, Johansen JS, Kjaer SK, Price PA, Christensen L, Blaakaer J, Bock JE, Glud E and Høgdall CK: High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncol Rep 10: 1535-1538, 2003.
APA
Høgdall, E.V., Johansen, J.S., Kjaer, S.K., Price, P.A., Christensen, L., Blaakaer, J. ... Høgdall, C.K. (2003). High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncology Reports, 10, 1535-1538. https://doi.org/10.3892/or.10.5.1535
MLA
Høgdall, E. V., Johansen, J. S., Kjaer, S. K., Price, P. A., Christensen, L., Blaakaer, J., Bock, J. E., Glud, E., Høgdall, C. K."High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival". Oncology Reports 10.5 (2003): 1535-1538.
Chicago
Høgdall, E. V., Johansen, J. S., Kjaer, S. K., Price, P. A., Christensen, L., Blaakaer, J., Bock, J. E., Glud, E., Høgdall, C. K."High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival". Oncology Reports 10, no. 5 (2003): 1535-1538. https://doi.org/10.3892/or.10.5.1535
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