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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2003 Volume 10 Issue 5

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Article

The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells

  • Authors:
    • Yuan-Shan Zhu
    • Ying Huang
    • Li-Qun Cai
    • Jeff Zhu
    • Quwen Duan
    • Yanwen Duan
    • Julianne Imperato-McGinley

  • View Affiliations / Copyright

    Affiliations: Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA. yuz2002@med.cornell.edu
  • Pages: 1633-1639
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1633
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Abstract

Prostate cancer is a leading cause of cancer death in American males. Currently, there is no curative therapy available once prostate cancer has metastasized. A major systemic therapy for metastatic prostate cancer is anti-androgen therapy. Unfortunately this therapy is only palliative and rarely curative, and eventually the tumor cells develop resistance to further hormone manipulation. It is therefore imperative to develop alternative effective therapies. In the present study, the effect of a Chinese herbal formula, ZYD88, on regulation of cell growth and cell apoptosis was examined in prostatic tumor cells. ZYD88 decreased cell viability of multiple prostatic tumor cell lines, DU-145, PC-3, MDA-PCa 2b and LNCaP in a time- and dose-dependent manner. It also produced a rapid and dose-dependent increase in caspase 3 activity in LNCaP and PC-3 cells, and induced DNA fragmentation in LNCaP cells, indicating cell apoptosis. In cotransfection assays, ZYD88 inhibited androgen-induced prostate specific antigen (PSA) gene promoter activity, and induced estrogen-target gene promoter activity. These data suggest that ZYD88 is a potential agent for prostate cancer therapy, and deserves further study.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Huang Y, Cai L, Zhu J, Duan Q, Duan Y and Imperato-McGinley J: The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells. Oncol Rep 10: 1633-1639, 2003.
APA
Zhu, Y., Huang, Y., Cai, L., Zhu, J., Duan, Q., Duan, Y., & Imperato-McGinley, J. (2003). The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells. Oncology Reports, 10, 1633-1639. https://doi.org/10.3892/or.10.5.1633
MLA
Zhu, Y., Huang, Y., Cai, L., Zhu, J., Duan, Q., Duan, Y., Imperato-McGinley, J."The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells". Oncology Reports 10.5 (2003): 1633-1639.
Chicago
Zhu, Y., Huang, Y., Cai, L., Zhu, J., Duan, Q., Duan, Y., Imperato-McGinley, J."The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells". Oncology Reports 10, no. 5 (2003): 1633-1639. https://doi.org/10.3892/or.10.5.1633
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Huang Y, Cai L, Zhu J, Duan Q, Duan Y and Imperato-McGinley J: The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells. Oncol Rep 10: 1633-1639, 2003.
APA
Zhu, Y., Huang, Y., Cai, L., Zhu, J., Duan, Q., Duan, Y., & Imperato-McGinley, J. (2003). The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells. Oncology Reports, 10, 1633-1639. https://doi.org/10.3892/or.10.5.1633
MLA
Zhu, Y., Huang, Y., Cai, L., Zhu, J., Duan, Q., Duan, Y., Imperato-McGinley, J."The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells". Oncology Reports 10.5 (2003): 1633-1639.
Chicago
Zhu, Y., Huang, Y., Cai, L., Zhu, J., Duan, Q., Duan, Y., Imperato-McGinley, J."The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells". Oncology Reports 10, no. 5 (2003): 1633-1639. https://doi.org/10.3892/or.10.5.1633
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