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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2003 Volume 10 Issue 5

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Article

Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma

  • Authors:
    • Jan Åhlén
    • Wendy W.-H. Weng
    • Otte Brosjö
    • Anette Von Rosen
    • Olle Larsson
    • Catharina Larsson

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, CMM L8:01 Karolinska Hospital, SE-171 76 Stockholm, Sweden. jan.ahlen@kirurgi.ki.se
  • Pages: 1641-1645
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1641
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Abstract

In this study 65 primary malignant fibrous histiocytomas (MFH) of high malignancy grade were characterized by immunohistochemistry for their expression of proteins reflecting or promoting tumor growth. The results were evaluated in relation to the disease-free survival and the occurrence of metastases alone or in combination with local recurrences during follow-up. A tumor size >8 cm was strongly associated with both a shorter disease-free survival (p=0.001) and a higher frequency of metastases alone or together with local recurrence during follow-up (p=0.001 and 0.004). Similarly a higher frequency of mitosis was associated with a shorter disease-free survival (p=0.004), while the presence of necrosis or malignancy grade 4 did not affect the clinical outcome. No significant effect on the clinical outcome was seen for p53, Ki-67, p27 expression or for vascular density determined by factor VIII staining. However, a significant association was demonstrated between high Bcl2 expression and the risk to develop both local recurrence and metastases (p=0.026). Taken together, the findings support the importance of the tumor size, and suggest that bcl2 staining but not p53, Ki-67, p27, vascular density or distinction of grade 3 and grade 4 tumors are of clinical value in the prognostication of MFH tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Åhlén J, Weng WW, Brosjö O, Von Rosen A, Larsson O and Larsson C: Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. Oncol Rep 10: 1641-1645, 2003.
APA
Åhlén, J., Weng, W.W., Brosjö, O., Von Rosen, A., Larsson, O., & Larsson, C. (2003). Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. Oncology Reports, 10, 1641-1645. https://doi.org/10.3892/or.10.5.1641
MLA
Åhlén, J., Weng, W. W., Brosjö, O., Von Rosen, A., Larsson, O., Larsson, C."Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma". Oncology Reports 10.5 (2003): 1641-1645.
Chicago
Åhlén, J., Weng, W. W., Brosjö, O., Von Rosen, A., Larsson, O., Larsson, C."Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma". Oncology Reports 10, no. 5 (2003): 1641-1645. https://doi.org/10.3892/or.10.5.1641
Copy and paste a formatted citation
x
Spandidos Publications style
Åhlén J, Weng WW, Brosjö O, Von Rosen A, Larsson O and Larsson C: Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. Oncol Rep 10: 1641-1645, 2003.
APA
Åhlén, J., Weng, W.W., Brosjö, O., Von Rosen, A., Larsson, O., & Larsson, C. (2003). Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. Oncology Reports, 10, 1641-1645. https://doi.org/10.3892/or.10.5.1641
MLA
Åhlén, J., Weng, W. W., Brosjö, O., Von Rosen, A., Larsson, O., Larsson, C."Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma". Oncology Reports 10.5 (2003): 1641-1645.
Chicago
Åhlén, J., Weng, W. W., Brosjö, O., Von Rosen, A., Larsson, O., Larsson, C."Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma". Oncology Reports 10, no. 5 (2003): 1641-1645. https://doi.org/10.3892/or.10.5.1641
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