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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2003 Volume 10 Issue 5

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Article

GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity

  • Authors:
    • M. J. Diament
    • M. I. Stillitani
    • L. Puricelli
    • E. Bal de Kier-Joffe
    • S. Klein

  • View Affiliations / Copyright

    Affiliations: Area Investigación, Instituto de Oncología AH Roffo, (1417) Buenos Aires, Argentina. bioterioroffo@yahoo.com
  • Pages: 1647-1652
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1647
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Abstract

During tumor development, growth factors may act in autocrine manner stimulating cell proliferation, or in paracrine manner affecting the microenvironment of the tumor and modulating the immune system. Murine mammary adenocarcinoma M3 tumor bearers develop lung metastases and leukocytosis during its evolution. Previously we described that M3 conditioned media enhanced metastasis incidence, when it was inoculated in tumor-operated mice. In the present study we determine that spleen cells from M3 tumor operated mice treated with M3 conditioned media, were able to transfer the capacity to enhance metastasis to other tumor operated mice. Spleen cells have immune suppressor activity that could be reversed by cyclophosfamide treatment. M3 tumor cells secrete GM-CSF, which is able to promote in vitro proliferation of M3 cells as well as spleen cells. This proliferation could be abrogated by the addition of anti-GM-CSF. We report that the GM-CSF secreted by M3 tumor cells had stimulatory activity on M3 tumor cell and lymphocyte proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Diament MJ, Stillitani MI, Puricelli L, Bal de Kier-Joffe E and Klein S: GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity. Oncol Rep 10: 1647-1652, 2003.
APA
Diament, M.J., Stillitani, M.I., Puricelli, L., Bal de Kier-Joffe, E., & Klein, S. (2003). GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity. Oncology Reports, 10, 1647-1652. https://doi.org/10.3892/or.10.5.1647
MLA
Diament, M. J., Stillitani, M. I., Puricelli, L., Bal de Kier-Joffe, E., Klein, S."GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity". Oncology Reports 10.5 (2003): 1647-1652.
Chicago
Diament, M. J., Stillitani, M. I., Puricelli, L., Bal de Kier-Joffe, E., Klein, S."GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity". Oncology Reports 10, no. 5 (2003): 1647-1652. https://doi.org/10.3892/or.10.5.1647
Copy and paste a formatted citation
x
Spandidos Publications style
Diament MJ, Stillitani MI, Puricelli L, Bal de Kier-Joffe E and Klein S: GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity. Oncol Rep 10: 1647-1652, 2003.
APA
Diament, M.J., Stillitani, M.I., Puricelli, L., Bal de Kier-Joffe, E., & Klein, S. (2003). GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity. Oncology Reports, 10, 1647-1652. https://doi.org/10.3892/or.10.5.1647
MLA
Diament, M. J., Stillitani, M. I., Puricelli, L., Bal de Kier-Joffe, E., Klein, S."GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity". Oncology Reports 10.5 (2003): 1647-1652.
Chicago
Diament, M. J., Stillitani, M. I., Puricelli, L., Bal de Kier-Joffe, E., Klein, S."GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity". Oncology Reports 10, no. 5 (2003): 1647-1652. https://doi.org/10.3892/or.10.5.1647
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