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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2004 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 11 Issue 1

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Article

Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas

  • Authors:
    • Supawadee Put-Ti-Noi
    • Songsak Petmitr
    • Voravut Chanyavanich
    • Tumtip Sangruji
    • Veerasak Theerapuncharoen
    • Kenshi Hayashi
    • Wipawan Thangnipon

  • View Affiliations / Copyright

    Affiliations: Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Bangkok, Thailand
  • Pages: 207-211
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/or.11.1.207
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Abstract

The tumor suppressor gene locus is known to be partly responsible for the tumorigenesis of sporadic gliomas, but the genetic events that drive the neoplastic process of this tumor remain largely unknown. We correlated the results of loss of heterozygosity (LOH) analysis on chromosomes 10 and 17 and a point mutation analysis of a tumor suppressor gene, p53, in 21 patients with astrocytomas at different stages. LOH was determined in tumor and leukocyte DNAs of primary human central nervous system tumors. The incidence rate of brain tumors corresponded to every p53-coding exon for single-strand conformation polymorphisms (SSCP) and the mutations were confirmed by sequencing. p53 mutations were found in 2 of 10 glioblastomas (20%) and in 1 of 8 low-grade astrocytomas (12.5%). Similarly, LOH on chromosome 10 was also found in 2 of 10 glioblastomas (20%) and 1 of 8 low-grade astocytomas (12.5%). Neither of the p53 mutations nor LOH on chromosome 10 was observed together in the tumor types analyzed. Interestingly, the p53 mutations were found in 29% of patients with LOH on chromosome 17. The fact that p53 mutation and LOH on chromosome 17 were found together only in glioblastomas, suggested that these genetic changes may accumulate during astrocytoma progression.

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Copy and paste a formatted citation
Spandidos Publications style
Put-Ti-Noi S, Petmitr S, Chanyavanich V, Sangruji T, Theerapuncharoen V, Hayashi K and Thangnipon W: Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas. Oncol Rep 11: 207-211, 2004.
APA
Put-Ti-Noi, S., Petmitr, S., Chanyavanich, V., Sangruji, T., Theerapuncharoen, V., Hayashi, K., & Thangnipon, W. (2004). Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas. Oncology Reports, 11, 207-211. https://doi.org/10.3892/or.11.1.207
MLA
Put-Ti-Noi, S., Petmitr, S., Chanyavanich, V., Sangruji, T., Theerapuncharoen, V., Hayashi, K., Thangnipon, W."Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas". Oncology Reports 11.1 (2004): 207-211.
Chicago
Put-Ti-Noi, S., Petmitr, S., Chanyavanich, V., Sangruji, T., Theerapuncharoen, V., Hayashi, K., Thangnipon, W."Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas". Oncology Reports 11, no. 1 (2004): 207-211. https://doi.org/10.3892/or.11.1.207
Copy and paste a formatted citation
x
Spandidos Publications style
Put-Ti-Noi S, Petmitr S, Chanyavanich V, Sangruji T, Theerapuncharoen V, Hayashi K and Thangnipon W: Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas. Oncol Rep 11: 207-211, 2004.
APA
Put-Ti-Noi, S., Petmitr, S., Chanyavanich, V., Sangruji, T., Theerapuncharoen, V., Hayashi, K., & Thangnipon, W. (2004). Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas. Oncology Reports, 11, 207-211. https://doi.org/10.3892/or.11.1.207
MLA
Put-Ti-Noi, S., Petmitr, S., Chanyavanich, V., Sangruji, T., Theerapuncharoen, V., Hayashi, K., Thangnipon, W."Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas". Oncology Reports 11.1 (2004): 207-211.
Chicago
Put-Ti-Noi, S., Petmitr, S., Chanyavanich, V., Sangruji, T., Theerapuncharoen, V., Hayashi, K., Thangnipon, W."Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas". Oncology Reports 11, no. 1 (2004): 207-211. https://doi.org/10.3892/or.11.1.207
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