Analysis of the RNA helicase A gene in human lung cancer

  • Authors:
    • Xiao Wei
    • Manuela Pacyna-Gengelbach
    • Karsten Schlüns
    • Qian An
    • Yanning Gao
    • Shujun Cheng
    • Iver Petersen
  • View Affiliations

  • Published online on: January 1, 2004     https://doi.org/10.3892/or.11.1.253
  • Pages: 253-258
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In this study we investigated the RNA helicase A (RHA) gene localized on chromosome 1q25 in 15 lung cancer cell lines, 54 primary carcinomas, bronchial epithelial cells and normal lung. Both RT-PCR and real-time RT-PCR showed that RHA is over-expressed in tumour samples compared to normal lung tissues (p=0.01). There was a tendency for higher expression levels in small cell lung cancer compared to non-small cell carcinomas. Over-expression of Y-162 correlated with high grade tumours (p=0.023). However, there was no correlation with tumour stage and survival. Our observations are compatible with the role of RHA in lung cancer development.

Related Articles

Journal Cover

January 2004
Volume 11 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wei X, Pacyna-Gengelbach M, Schlüns K, An Q, Gao Y, Cheng S and Petersen I: Analysis of the RNA helicase A gene in human lung cancer. Oncol Rep 11: 253-258, 2004
APA
Wei, X., Pacyna-Gengelbach, M., Schlüns, K., An, Q., Gao, Y., Cheng, S., & Petersen, I. (2004). Analysis of the RNA helicase A gene in human lung cancer. Oncology Reports, 11, 253-258. https://doi.org/10.3892/or.11.1.253
MLA
Wei, X., Pacyna-Gengelbach, M., Schlüns, K., An, Q., Gao, Y., Cheng, S., Petersen, I."Analysis of the RNA helicase A gene in human lung cancer". Oncology Reports 11.1 (2004): 253-258.
Chicago
Wei, X., Pacyna-Gengelbach, M., Schlüns, K., An, Q., Gao, Y., Cheng, S., Petersen, I."Analysis of the RNA helicase A gene in human lung cancer". Oncology Reports 11, no. 1 (2004): 253-258. https://doi.org/10.3892/or.11.1.253