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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2004 Volume 11 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2004 Volume 11 Issue 5

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Article

Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells

  • Authors:
    • Takemi Otsuki
    • Haruko Sakaguchi
    • Tamayo Hatayama
    • Tomohiro Fujii
    • Takayuki Tsujioka
    • Takashi Sugihara
    • Akiko Takata
    • Fuminori Hyodoh
    • Masaaki Eto

  • View Affiliations / Copyright

    Affiliations: Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. takemi@med.kawasaki-m.ac.jp
  • Pages: 1053-1058
    |
    Published online on: May 1, 2004
       https://doi.org/10.3892/or.11.5.1053
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Abstract

To look for new candidates for agents to use in maintenance therapy for myeloma patients, the growth inhibitory effects of a 3-hydroxy-3-mehtylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin), simvastatin, was analyzed using human myeloma cell lines. Several investigations have indicated growth reduction in certain lineages of cancer cells including one report on myeloma, and inhibitory effects of statins on GTPases and involving MAP-kinases. Most (12 out of 13) myeloma lines examined showed growth inhibition when cultured with various concentrations (1-30 µM) of simvastatin in a dose-dependent manner. Simvastatin in combination with other biological response modifiers such as ATRA or DEX had additional effects on growth. In addition, anti-oxides prevented the simvastatin-induced growth inhibition and apoptosis. Furthermore, myeloma cells treated with simvastatin clearly showed inactivation of various MAP-kinase pathways such as ERK1/2, MEK1/2, JNK, and p38. Based on these findings, statins may be suitable for clinical usage in maintenance therapy for myeloma patients.

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Copy and paste a formatted citation
Spandidos Publications style
Otsuki T, Sakaguchi H, Hatayama T, Fujii T, Tsujioka T, Sugihara T, Takata A, Hyodoh F and Eto M: Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. Oncol Rep 11: 1053-1058, 2004.
APA
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T. ... Eto, M. (2004). Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. Oncology Reports, 11, 1053-1058. https://doi.org/10.3892/or.11.5.1053
MLA
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T., Takata, A., Hyodoh, F., Eto, M."Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells". Oncology Reports 11.5 (2004): 1053-1058.
Chicago
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T., Takata, A., Hyodoh, F., Eto, M."Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells". Oncology Reports 11, no. 5 (2004): 1053-1058. https://doi.org/10.3892/or.11.5.1053
Copy and paste a formatted citation
x
Spandidos Publications style
Otsuki T, Sakaguchi H, Hatayama T, Fujii T, Tsujioka T, Sugihara T, Takata A, Hyodoh F and Eto M: Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. Oncol Rep 11: 1053-1058, 2004.
APA
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T. ... Eto, M. (2004). Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. Oncology Reports, 11, 1053-1058. https://doi.org/10.3892/or.11.5.1053
MLA
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T., Takata, A., Hyodoh, F., Eto, M."Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells". Oncology Reports 11.5 (2004): 1053-1058.
Chicago
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T., Takata, A., Hyodoh, F., Eto, M."Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells". Oncology Reports 11, no. 5 (2004): 1053-1058. https://doi.org/10.3892/or.11.5.1053
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