Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells

  • Authors:
    • Takemi Otsuki
    • Haruko Sakaguchi
    • Tamayo Hatayama
    • Tomohiro Fujii
    • Takayuki Tsujioka
    • Takashi Sugihara
    • Akiko Takata
    • Fuminori Hyodoh
    • Masaaki Eto
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/or.11.5.1053
  • Pages: 1053-1058
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Abstract

To look for new candidates for agents to use in maintenance therapy for myeloma patients, the growth inhibitory effects of a 3-hydroxy-3-mehtylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin), simvastatin, was analyzed using human myeloma cell lines. Several investigations have indicated growth reduction in certain lineages of cancer cells including one report on myeloma, and inhibitory effects of statins on GTPases and involving MAP-kinases. Most (12 out of 13) myeloma lines examined showed growth inhibition when cultured with various concentrations (1-30 µM) of simvastatin in a dose-dependent manner. Simvastatin in combination with other biological response modifiers such as ATRA or DEX had additional effects on growth. In addition, anti-oxides prevented the simvastatin-induced growth inhibition and apoptosis. Furthermore, myeloma cells treated with simvastatin clearly showed inactivation of various MAP-kinase pathways such as ERK1/2, MEK1/2, JNK, and p38. Based on these findings, statins may be suitable for clinical usage in maintenance therapy for myeloma patients.

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May 2004
Volume 11 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Otsuki T, Sakaguchi H, Hatayama T, Fujii T, Tsujioka T, Sugihara T, Takata A, Hyodoh F and Eto M: Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. Oncol Rep 11: 1053-1058, 2004
APA
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T. ... Eto, M. (2004). Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. Oncology Reports, 11, 1053-1058. https://doi.org/10.3892/or.11.5.1053
MLA
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T., Takata, A., Hyodoh, F., Eto, M."Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells". Oncology Reports 11.5 (2004): 1053-1058.
Chicago
Otsuki, T., Sakaguchi, H., Hatayama, T., Fujii, T., Tsujioka, T., Sugihara, T., Takata, A., Hyodoh, F., Eto, M."Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells". Oncology Reports 11, no. 5 (2004): 1053-1058. https://doi.org/10.3892/or.11.5.1053