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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2004 Volume 11 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2004 Volume 11 Issue 5

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Article

The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer

  • Authors:
    • Juichiro Konishi
    • Shinichi Toyooka
    • Motoi Aoe
    • Yasushi Omura
    • Kazuhiro Washio
    • Kazunori Tsukuda
    • Nobuyoshi Shimizu

  • View Affiliations / Copyright

    Affiliations: Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
  • Pages: 1063-1067
    |
    Published online on: May 1, 2004
       https://doi.org/10.3892/or.11.5.1063
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Abstract

Tumor-associated antigens recognized by cellular or humoral effectors of the immune system are potential targets for antigen-specific cancer immunotherapy. NY-ESO-1 is one of the most immunogenic cancer/testis (CT) antigens and emerges as the potential candidate for specific immunotherapy. We studied mRNA expression status of NY-ESO-1 in 63 cases of NSCLCs using the real-time reverse transcription PCR to examine the relationship between its expression and clinicopathological features. NY-ESO-1 expression was present in 20 (32%) of 63 NSCLC cases and significantly increased with the advancement of disease stage in TNM classification (P=0.013), especially related to lymph node metastasis (P=0.020). Moreover, frequency of NY-ESO-1 expression was related to the degree of pathological differentiation (P=0.035). The quantity of NY-ESO-1 expression by real-time RT-PCR was not correlated with any clinicopathological factor. Our results demonstrate that the NY-ESO-1 expression was frequently present in primary NSCLC, especially advanced cases with lymph node metastasis. In addition, the high incidence of NY-ESO-1 expression in NSCLC suggests the possibility of a specific immunotherapy for NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Konishi J, Toyooka S, Aoe M, Omura Y, Washio K, Tsukuda K and Shimizu N: The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncol Rep 11: 1063-1067, 2004.
APA
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., & Shimizu, N. (2004). The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncology Reports, 11, 1063-1067. https://doi.org/10.3892/or.11.5.1063
MLA
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., Shimizu, N."The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer". Oncology Reports 11.5 (2004): 1063-1067.
Chicago
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., Shimizu, N."The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer". Oncology Reports 11, no. 5 (2004): 1063-1067. https://doi.org/10.3892/or.11.5.1063
Copy and paste a formatted citation
x
Spandidos Publications style
Konishi J, Toyooka S, Aoe M, Omura Y, Washio K, Tsukuda K and Shimizu N: The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncol Rep 11: 1063-1067, 2004.
APA
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., & Shimizu, N. (2004). The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncology Reports, 11, 1063-1067. https://doi.org/10.3892/or.11.5.1063
MLA
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., Shimizu, N."The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer". Oncology Reports 11.5 (2004): 1063-1067.
Chicago
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., Shimizu, N."The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer". Oncology Reports 11, no. 5 (2004): 1063-1067. https://doi.org/10.3892/or.11.5.1063
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