The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer

  • Authors:
    • Juichiro Konishi
    • Shinichi Toyooka
    • Motoi Aoe
    • Yasushi Omura
    • Kazuhiro Washio
    • Kazunori Tsukuda
    • Nobuyoshi Shimizu
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/or.11.5.1063
  • Pages: 1063-1067
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Abstract

Tumor-associated antigens recognized by cellular or humoral effectors of the immune system are potential targets for antigen-specific cancer immunotherapy. NY-ESO-1 is one of the most immunogenic cancer/testis (CT) antigens and emerges as the potential candidate for specific immunotherapy. We studied mRNA expression status of NY-ESO-1 in 63 cases of NSCLCs using the real-time reverse transcription PCR to examine the relationship between its expression and clinicopathological features. NY-ESO-1 expression was present in 20 (32%) of 63 NSCLC cases and significantly increased with the advancement of disease stage in TNM classification (P=0.013), especially related to lymph node metastasis (P=0.020). Moreover, frequency of NY-ESO-1 expression was related to the degree of pathological differentiation (P=0.035). The quantity of NY-ESO-1 expression by real-time RT-PCR was not correlated with any clinicopathological factor. Our results demonstrate that the NY-ESO-1 expression was frequently present in primary NSCLC, especially advanced cases with lymph node metastasis. In addition, the high incidence of NY-ESO-1 expression in NSCLC suggests the possibility of a specific immunotherapy for NSCLC.

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May 2004
Volume 11 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Konishi J, Toyooka S, Aoe M, Omura Y, Washio K, Tsukuda K and Shimizu N: The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncol Rep 11: 1063-1067, 2004.
APA
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., & Shimizu, N. (2004). The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer. Oncology Reports, 11, 1063-1067. https://doi.org/10.3892/or.11.5.1063
MLA
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., Shimizu, N."The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer". Oncology Reports 11.5 (2004): 1063-1067.
Chicago
Konishi, J., Toyooka, S., Aoe, M., Omura, Y., Washio, K., Tsukuda, K., Shimizu, N."The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer". Oncology Reports 11, no. 5 (2004): 1063-1067. https://doi.org/10.3892/or.11.5.1063