Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils

  • Authors:
    • Yoshinori Tanaka
    • Harushi Osugi
    • Keiichirou Morimura
    • Masashi Takemura
    • Masakatsu Ueno
    • Masahiro Kaneko
    • Shoji Fukushima
    • Hiroaki Kinoshita
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/or.11.5.965
  • Pages: 965-971
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Both Helicobacter pylori (Hp) and bile acids are gastric carcinogens. An experimental model of duodenogastric reflux in Mongolian gerbils was developed and was used to study the effects of Hp infection and duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced glandular stomach tumorigenesis independently and synergistically. Male Mongolian gerbils underwent both inoculation with Hp, and had duodenogastric reflux (DR) induced, or neither, followed by MNNG administration. Animals were sacrificed at week 40, and histopathological examination of their excised stomachs and serological investigation were performed. Glandular stomach adenocarcinomas were observed in animals that underwent Hp inoculation and/or induction of DR after MNNG administration, and glandular stomach adenomas were found in animals inoculated with Hp after MNNG administration. The incidence of glandular stomach tumors was significantly higher in animals inoculated with Hp after MNNG administration and in animals undergoing combined Hp inoculation, DR induction and MNNG administration than in animals only administered MNNG. These findings indicate that Hp infection has a stronger tumorigenic effect than the exposure to duodenal contents, and duodenal contents may attenuate the effect of Hp on glandular stomach tumorigenesis.

Related Articles

Journal Cover

May 2004
Volume 11 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka Y, Osugi H, Morimura K, Takemura M, Ueno M, Kaneko M, Fukushima S and Kinoshita H: Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. Oncol Rep 11: 965-971, 2004.
APA
Tanaka, Y., Osugi, H., Morimura, K., Takemura, M., Ueno, M., Kaneko, M. ... Kinoshita, H. (2004). Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. Oncology Reports, 11, 965-971. https://doi.org/10.3892/or.11.5.965
MLA
Tanaka, Y., Osugi, H., Morimura, K., Takemura, M., Ueno, M., Kaneko, M., Fukushima, S., Kinoshita, H."Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils". Oncology Reports 11.5 (2004): 965-971.
Chicago
Tanaka, Y., Osugi, H., Morimura, K., Takemura, M., Ueno, M., Kaneko, M., Fukushima, S., Kinoshita, H."Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils". Oncology Reports 11, no. 5 (2004): 965-971. https://doi.org/10.3892/or.11.5.965