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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2004 Volume 11 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 11 Issue 6

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Article

Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells

  • Authors:
    • Tokuhiro Chano
    • Kanji Mori
    • Katia Scotlandi
    • Stefania Benini
    • Cristina Lapucci
    • Maria Cristina Manara
    • Massimo Serra
    • Piero Picci
    • Hidetoshi Okabe
    • Nicola Baldini

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan. chano@belle.shiga-med.ac.jp
  • Pages: 1257-1263
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/or.11.6.1257
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Abstract

Multidrug resistance (MDR) to anticancer agents is a major barrier to the successful treatment of human osteosarcomas. Current understanding of the genes that contribute to the features of MDR is limited, and the mechanisms remain unclear. Here we applied differential display reverse transcription-polymerase chain reaction (DDRT-PCR) to parental and MDR-variants of U-2 OS human osteosarcoma cells, to clarify the genes involved in the MDR cells, and identified five candidate genes. These are BCRP (breast cancer resistance protein) encoding a transmembrane efflux pump; RB1CC1 (RB1-inducible coiled-coil 1), a tumor suppressor regulating RB1 (retinoblastoma 1) expression; a novel transcriptional variant of dUTPase; SSR2 (β-signal sequence receptor), which is associated with protein translocation across ER membrane; and HSP105 encoding high molecular mass heat shock proteins. Molecular and biological characterization of these genes will yield further insight into the features between MDR and tumor progression in human osteosarcomas.

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Copy and paste a formatted citation
Spandidos Publications style
Chano T, Mori K, Scotlandi K, Benini S, Lapucci C, Manara MC, Serra M, Picci P, Okabe H, Baldini N, Baldini N, et al: Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. Oncol Rep 11: 1257-1263, 2004.
APA
Chano, T., Mori, K., Scotlandi, K., Benini, S., Lapucci, C., Manara, M.C. ... Baldini, N. (2004). Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. Oncology Reports, 11, 1257-1263. https://doi.org/10.3892/or.11.6.1257
MLA
Chano, T., Mori, K., Scotlandi, K., Benini, S., Lapucci, C., Manara, M. C., Serra, M., Picci, P., Okabe, H., Baldini, N."Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells". Oncology Reports 11.6 (2004): 1257-1263.
Chicago
Chano, T., Mori, K., Scotlandi, K., Benini, S., Lapucci, C., Manara, M. C., Serra, M., Picci, P., Okabe, H., Baldini, N."Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells". Oncology Reports 11, no. 6 (2004): 1257-1263. https://doi.org/10.3892/or.11.6.1257
Copy and paste a formatted citation
x
Spandidos Publications style
Chano T, Mori K, Scotlandi K, Benini S, Lapucci C, Manara MC, Serra M, Picci P, Okabe H, Baldini N, Baldini N, et al: Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. Oncol Rep 11: 1257-1263, 2004.
APA
Chano, T., Mori, K., Scotlandi, K., Benini, S., Lapucci, C., Manara, M.C. ... Baldini, N. (2004). Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. Oncology Reports, 11, 1257-1263. https://doi.org/10.3892/or.11.6.1257
MLA
Chano, T., Mori, K., Scotlandi, K., Benini, S., Lapucci, C., Manara, M. C., Serra, M., Picci, P., Okabe, H., Baldini, N."Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells". Oncology Reports 11.6 (2004): 1257-1263.
Chicago
Chano, T., Mori, K., Scotlandi, K., Benini, S., Lapucci, C., Manara, M. C., Serra, M., Picci, P., Okabe, H., Baldini, N."Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells". Oncology Reports 11, no. 6 (2004): 1257-1263. https://doi.org/10.3892/or.11.6.1257
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