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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2004 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2004 Volume 12 Issue 1

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Article

Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers

  • Authors:
    • Hio Chung Kang
    • Il-Jin Kim
    • Jae-Hyun Park
    • Yong Shin
    • Hye-Won Park
    • Ja-Lok Ku
    • Han-Kwang Yang
    • Kuhn Uk Lee
    • Kuk Jin Choe
    • Jae-Gahb Park

  • View Affiliations / Copyright

    Affiliations: Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University, Chongno-gu, Seoul 110-799, Korea
  • Pages: 129-133
    |
    Published online on: July 1, 2004
       https://doi.org/10.3892/or.12.1.129
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Abstract

CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, whereas loss of CHFR expression has been observed in human tumors. Silencing of CHFR has been associated with aberrant promoter methylation and histone deacetylation in several cancer types. In this study, we investigated epigenetic CHFR inactivation in human gastric cancers by examining CHFR expression and methylation status in gastric cancer cell lines with RT-PCR analysis, bisulfite PCR and sequencing. A series of primary gastric tumors were also analyzed for CHFR methylation. Eight of 12 (66.7%) gastric cancer cell lines and 19/43 (44.2%) primary gastric tumors showed CHFR methylation. In addition, CpG methylation status correlated well with CHFR expression in the human gastric cancer cell lines, in which treatment with 5-aza-dC resulted in de novo or enhanced expression of CHFR. Combination treatment of 5-aza-dC with trichostatin A showed a synergistic effect on CHFR expression in some cases. Our results indicate that aberrant promoter methylation of the CHFR gene was observed in a significant proportion of human gastric cancers and was responsible for the inactivation of the CHFR gene in gastric cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Kang HC, Kim I, Park J, Shin Y, Park H, Ku J, Yang H, Lee KU, Choe KJ, Park J, Park J, et al: Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers. Oncol Rep 12: 129-133, 2004.
APA
Kang, H.C., Kim, I., Park, J., Shin, Y., Park, H., Ku, J. ... Park, J. (2004). Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers. Oncology Reports, 12, 129-133. https://doi.org/10.3892/or.12.1.129
MLA
Kang, H. C., Kim, I., Park, J., Shin, Y., Park, H., Ku, J., Yang, H., Lee, K. U., Choe, K. J., Park, J."Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncology Reports 12.1 (2004): 129-133.
Chicago
Kang, H. C., Kim, I., Park, J., Shin, Y., Park, H., Ku, J., Yang, H., Lee, K. U., Choe, K. J., Park, J."Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncology Reports 12, no. 1 (2004): 129-133. https://doi.org/10.3892/or.12.1.129
Copy and paste a formatted citation
x
Spandidos Publications style
Kang HC, Kim I, Park J, Shin Y, Park H, Ku J, Yang H, Lee KU, Choe KJ, Park J, Park J, et al: Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers. Oncol Rep 12: 129-133, 2004.
APA
Kang, H.C., Kim, I., Park, J., Shin, Y., Park, H., Ku, J. ... Park, J. (2004). Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers. Oncology Reports, 12, 129-133. https://doi.org/10.3892/or.12.1.129
MLA
Kang, H. C., Kim, I., Park, J., Shin, Y., Park, H., Ku, J., Yang, H., Lee, K. U., Choe, K. J., Park, J."Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncology Reports 12.1 (2004): 129-133.
Chicago
Kang, H. C., Kim, I., Park, J., Shin, Y., Park, H., Ku, J., Yang, H., Lee, K. U., Choe, K. J., Park, J."Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncology Reports 12, no. 1 (2004): 129-133. https://doi.org/10.3892/or.12.1.129
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