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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2004 Volume 12 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse

  • Authors:
    • Diana L. Hulboy
    • Shiva Gautam
    • Barbara Fingleton
    • Lynn M. Matrisian

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Biology, Division of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
  • Pages: 13-17
    |
    Published online on: July 1, 2004
       https://doi.org/10.3892/or.12.1.13
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Abstract

The multiple intestinal neoplasia (Min/+) mouse, which carries a mutant adenomatous polyposis coli (Apc) allele, is a model for human familial colon cancer. Like the human syndrome caused by mutant APC, the Min/+ mouse syndrome shows susceptibility to tumors of other tissues, including the mammary gland. The matrix metalloproteinase (MMP) MMP-7 (matrilysin) gene is transcriptionally induced by signal transduction pathways resulting from loss of APC function, and contributes to the progression of benign and malignant intestinal epithelial cells. Mammary tumors that develop in Min/+ mice express MMP-7. To investigate whether mutant APC and MMP-7 can cooperate in mammary tumorigenesis, we compared N-ethyl-N-nitrosourea (ENU)-enhanced mammary tumor formation in Min/+ mice that were either wild-type or deficient in MMP-7. Min/+ mice lacking MMP-7 demonstrate a 60% reduction in the number of early focal lesions in the mammary gland at early, but not later, timepoints. We conclude that MMP-7 transiently influences early stage mammary tumorigenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Hulboy DL, Gautam S, Fingleton B and Matrisian LM: The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep 12: 13-17, 2004.
APA
Hulboy, D.L., Gautam, S., Fingleton, B., & Matrisian, L.M. (2004). The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncology Reports, 12, 13-17. https://doi.org/10.3892/or.12.1.13
MLA
Hulboy, D. L., Gautam, S., Fingleton, B., Matrisian, L. M."The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse". Oncology Reports 12.1 (2004): 13-17.
Chicago
Hulboy, D. L., Gautam, S., Fingleton, B., Matrisian, L. M."The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse". Oncology Reports 12, no. 1 (2004): 13-17. https://doi.org/10.3892/or.12.1.13
Copy and paste a formatted citation
x
Spandidos Publications style
Hulboy DL, Gautam S, Fingleton B and Matrisian LM: The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep 12: 13-17, 2004.
APA
Hulboy, D.L., Gautam, S., Fingleton, B., & Matrisian, L.M. (2004). The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncology Reports, 12, 13-17. https://doi.org/10.3892/or.12.1.13
MLA
Hulboy, D. L., Gautam, S., Fingleton, B., Matrisian, L. M."The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse". Oncology Reports 12.1 (2004): 13-17.
Chicago
Hulboy, D. L., Gautam, S., Fingleton, B., Matrisian, L. M."The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse". Oncology Reports 12, no. 1 (2004): 13-17. https://doi.org/10.3892/or.12.1.13
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