Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan

  • Authors:
    • Chihaya Koriyama
    • Suminori Akiba
    • Alejandro Corvalan
    • Edwin Carrascal
    • Tetsuhiko Itoh
    • Roberto Herrera-Goepfert
    • Yoshito Eizuru
    • Masayoshi Tokunaga
  • View Affiliations

  • Published online on: September 1, 2004     https://doi.org/10.3892/or.12.3.543
  • Pages: 543-547
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Abstract

We examined 1,918 Japanese gastric cancer cases diagnosed during the period 1976-1995 to clarify histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma (EBV-GC). EBV-GCs accounted for 4.5% and 6.1% of 1,088 intestinal-type and 830 diffuse-type gastric carcinomas, respectively. Both intestinal- and diffuse-type EBV-GCs showed male predominance, but the observed gender difference was statistically significant only in diffuse-type carcinomas (P<0.001). An age-dependent decrease of the EBV-GC proportion was observed in intestinal-type carcinomas (P=0.002), but not in diffuse-type carcinomas. In intestinal-type tumors, the estimated incidence of EBV-GCs reached its peak around age 70. Diffuse-type EBV-GCs appeared to have a much older peak incidence, if any. Both intestinal- and diffuse-type EBV-GCs were least prevalent in the stomach antrum. This study, examining the largest number of EBV-GCs in current literature, showed different patterns of age-dependence in intestinal- and diffuse-type EBV-GCs, suggesting that pathogenic pathways of EBV-GCs may be different in these 2 histological types.

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September 2004
Volume 12 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Koriyama C, Akiba S, Corvalan A, Carrascal E, Itoh T, Herrera-Goepfert R, Eizuru Y and Tokunaga M: Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan. Oncol Rep 12: 543-547, 2004.
APA
Koriyama, C., Akiba, S., Corvalan, A., Carrascal, E., Itoh, T., Herrera-Goepfert, R. ... Tokunaga, M. (2004). Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan. Oncology Reports, 12, 543-547. https://doi.org/10.3892/or.12.3.543
MLA
Koriyama, C., Akiba, S., Corvalan, A., Carrascal, E., Itoh, T., Herrera-Goepfert, R., Eizuru, Y., Tokunaga, M."Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan". Oncology Reports 12.3 (2004): 543-547.
Chicago
Koriyama, C., Akiba, S., Corvalan, A., Carrascal, E., Itoh, T., Herrera-Goepfert, R., Eizuru, Y., Tokunaga, M."Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan". Oncology Reports 12, no. 3 (2004): 543-547. https://doi.org/10.3892/or.12.3.543