Predicting the recurrence/metastasis of stage I and II breast cancer without lymph node metastasis

  • Authors:
    • Masaya Mukai
    • Shinkichi Sato
    • Tomomi Kimura
    • Nobukazu Komatsu
    • Hiromi Ninomiya
    • Hisao Nakasaki
    • Kyouji Ogoshi
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/or.12.4.745
  • Pages: 745-748
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Abstract

Prediction of the recurrence of primary breast cancer was attempted by detection of occult neoplastic cells (ONCs) in lymph nodes or by using the high-risk criteria for recurrence/metastasis of gastric and colorectal cancer. The subjects were 70 patients with stage I or II node-negative primary breast cancer. Prediction of recurrence using ONCs had a sensitivity of 60.0% (3/5) and a false-negative rate of 40.0% (2/5) in the recurrence group, while the specificity was 96.9% (63/65) and the false-positive rate was 3.1% (2/65) in the non-recurrence group. The accuracy of ONCs was 78.5%. Prediction of recurrence based on positivity for at least 2 of the high-risk criteria showed a sensitivity of 60.0% (3/5) and a false-negative rate of 40.0% (2/5) in the recurrence group, while the specificity was 95.4% (62/65) and the false-positive rate was 4.6% (3/65) in the non-recurrence group. The accuracy of the high-risk criteria was 77.7%. These results suggest that ONCs show the same accuracy as the high-risk criteria for predicting recurrence/metastasis of stage I and II node-negative breast cancer with a high specificity.

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October 2004
Volume 12 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mukai M, Sato S, Kimura T, Komatsu N, Ninomiya H, Nakasaki H, Ogoshi K and Makuuchi H: Predicting the recurrence/metastasis of stage I and II breast cancer without lymph node metastasis. Oncol Rep 12: 745-748, 2004
APA
Mukai, M., Sato, S., Kimura, T., Komatsu, N., Ninomiya, H., Nakasaki, H. ... Makuuchi, H. (2004). Predicting the recurrence/metastasis of stage I and II breast cancer without lymph node metastasis. Oncology Reports, 12, 745-748. https://doi.org/10.3892/or.12.4.745
MLA
Mukai, M., Sato, S., Kimura, T., Komatsu, N., Ninomiya, H., Nakasaki, H., Ogoshi, K., Makuuchi, H."Predicting the recurrence/metastasis of stage I and II breast cancer without lymph node metastasis". Oncology Reports 12.4 (2004): 745-748.
Chicago
Mukai, M., Sato, S., Kimura, T., Komatsu, N., Ninomiya, H., Nakasaki, H., Ogoshi, K., Makuuchi, H."Predicting the recurrence/metastasis of stage I and II breast cancer without lymph node metastasis". Oncology Reports 12, no. 4 (2004): 745-748. https://doi.org/10.3892/or.12.4.745