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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2004 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 12 Issue 4

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Article

GST-pi expression correlates with oxidative stress and apoptosis in breast cancer

  • Authors:
    • Jingxiang Huang
    • Puay Hoon Tan
    • Benny Kwong Huat Tan
    • Boon Huat Bay

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Faculty of Medicine, National University of Singapore, S117597, Singapore
  • Pages: 921-925
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/or.12.4.921
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Abstract

Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of reactive oxygen species (ROS). Thus, we assessed GST activity and GST-pi expression in relation to oxidative stress and apoptosis in breast cancer. Tumor tissues from 32 breast cancer patients were evaluated for GST activity and thiobarbituric acid reactive substances (TBARS) that are by-products of oxidative stress. Four-micron sections of formalin-fixed, paraffin embedded tumors were stained immunohistochemically with anti-GST-pi. Apoptotic cells were detected by in situ end labeling of DNA fragments using a commercial kit. TBARS levels were significantly higher in breast cancers of older patients. GST-pi expression was up-regulated in breast cancers that exhibited higher oxidative stress and associated with higher GST activity. Apoptosis in GST-pi negative tumors was not correlated with GST activity, but GST-pi positive tumors within the same range of oxidative stress showed a reduction in apoptosis as well as an increased GST activity. This correlation was absent in GST-pi positive tumors experiencing higher oxidative stress. GST-pi expression may influence the level of GST activity and delay apoptosis in breast cancer. However, GST-pi expression in tumors with higher levels of oxidative stress may not be sufficient to abrogate the deleterious effects of ROS.

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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Tan PH, Tan BK and Bay BH: GST-pi expression correlates with oxidative stress and apoptosis in breast cancer. Oncol Rep 12: 921-925, 2004.
APA
Huang, J., Tan, P.H., Tan, B.K., & Bay, B.H. (2004). GST-pi expression correlates with oxidative stress and apoptosis in breast cancer. Oncology Reports, 12, 921-925. https://doi.org/10.3892/or.12.4.921
MLA
Huang, J., Tan, P. H., Tan, B. K., Bay, B. H."GST-pi expression correlates with oxidative stress and apoptosis in breast cancer". Oncology Reports 12.4 (2004): 921-925.
Chicago
Huang, J., Tan, P. H., Tan, B. K., Bay, B. H."GST-pi expression correlates with oxidative stress and apoptosis in breast cancer". Oncology Reports 12, no. 4 (2004): 921-925. https://doi.org/10.3892/or.12.4.921
Copy and paste a formatted citation
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Spandidos Publications style
Huang J, Tan PH, Tan BK and Bay BH: GST-pi expression correlates with oxidative stress and apoptosis in breast cancer. Oncol Rep 12: 921-925, 2004.
APA
Huang, J., Tan, P.H., Tan, B.K., & Bay, B.H. (2004). GST-pi expression correlates with oxidative stress and apoptosis in breast cancer. Oncology Reports, 12, 921-925. https://doi.org/10.3892/or.12.4.921
MLA
Huang, J., Tan, P. H., Tan, B. K., Bay, B. H."GST-pi expression correlates with oxidative stress and apoptosis in breast cancer". Oncology Reports 12.4 (2004): 921-925.
Chicago
Huang, J., Tan, P. H., Tan, B. K., Bay, B. H."GST-pi expression correlates with oxidative stress and apoptosis in breast cancer". Oncology Reports 12, no. 4 (2004): 921-925. https://doi.org/10.3892/or.12.4.921
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