Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas

  • Authors:
    • Xiurong Tian
    • Kazushi Shigemasa
    • Eiji Hirata
    • Lijun Gu
    • Yoshimi Uebaba
    • Nobutaka Nagai
    • Timothy J. O'Brien
    • Koso Ohama
  • View Affiliations

  • Published online on: November 1, 2004     https://doi.org/10.3892/or.12.5.1001
  • Pages: 1001-1006
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Abstract

To investigate the potential role of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in the development and progression of uterine cervical adenocarcinoma, we examined hK7 and ALP protein expression by immunohistochemistry in 70 cervical adenocarcinomas and 13 normal cervical tissues. Positive hK7 expression rates in normal endocervical glands and in cervical adenocarcinomas were 46.2 and 80%, respectively. A significantly higher hK7 expression rate was observed in cervical adenocarcinomas compared to normal endocervical glands (p=0.0099). In contrast, positive ALP detection rates in normal endocervical glands and in cervical adenocarcinomas were 100 and 15.7%, respectively. A significantly lower ALP detection rate was observed in cervical adenocarcinomas compared to normal endocervical glands (p<0.0001). There was a significant inverse correlation between hK7 and ALP expression status (p=0.0010). However, no statistically significant differences in hK7 or ALP expression status were found with respect to age, clinical stage, histological grade and lymph node metastasis status in cervical adenocarcinoma cases. Log-rank testing showed that advanced clinical stage and positive lymph node metastasis significantly correlated with poor patient survival (p=0.0005 and p<0.0001, respectively), whereas no correlation was found between hK7 or ALP expression and survival. These results suggest that increased expression of hK7 and decreased expression of ALP might play an important role in cervical adenocarcinoma development.

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November 2004
Volume 12 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tian X, Shigemasa K, Hirata E, Gu L, Uebaba Y, Nagai N, O'Brien TJ and Ohama K: Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas. Oncol Rep 12: 1001-1006, 2004.
APA
Tian, X., Shigemasa, K., Hirata, E., Gu, L., Uebaba, Y., Nagai, N. ... Ohama, K. (2004). Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas. Oncology Reports, 12, 1001-1006. https://doi.org/10.3892/or.12.5.1001
MLA
Tian, X., Shigemasa, K., Hirata, E., Gu, L., Uebaba, Y., Nagai, N., O'Brien, T. J., Ohama, K."Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas". Oncology Reports 12.5 (2004): 1001-1006.
Chicago
Tian, X., Shigemasa, K., Hirata, E., Gu, L., Uebaba, Y., Nagai, N., O'Brien, T. J., Ohama, K."Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas". Oncology Reports 12, no. 5 (2004): 1001-1006. https://doi.org/10.3892/or.12.5.1001