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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2004 Volume 12 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin

  • Authors:
    • Mitsuho Imai
    • Tsutomu Nakamura
    • Tetsu Akiyama
    • Akira Horii

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8575, Japan
  • Pages: 1099-1103
    |
    Published online on: November 1, 2004
       https://doi.org/10.3892/or.12.5.1099
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Abstract

Abnormal nuclear accumulation of β-catenin (CTNNB1) plays one of the key roles in the upregulation of the Wnt signalling pathway that can cause acceleration of cell proliferation. ICAT, inhibitor of β-catenin and TCF4/β-catenin-interacting protein, was isolated and mapped to 1p36, a frequent target for LOH in many human cancers. We have previously observed that a number of tumors showing abnormal accumulation of the CTNNB1 protein do not harbor a mutation of the CTNNB1 gene. We studied the precise localization and genomic structure of the ICAT gene and analyzed its mutations in 178 human tumors developed in organs with frequent nuclear accumulation of the CTNNB1 protein and/or frequent LOHs of 1p36, but no genetic alterations were observed. Our results imply that i) genetic alteration of the ICAT gene does not play an important role in abnormal accumulation of CTNNB1 that would cause up-regulation of the Wnt signalling pathway, ii) mechanisms other than genetic alteration may have inactivated ICAT function, or iii) gene(s) on 1p36 other than ICAT may be the responsible tumor suppressor gene for tumors that show frequent 1p36-LOH.

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Copy and paste a formatted citation
Spandidos Publications style
Imai M, Nakamura T, Akiyama T and Horii A: Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. Oncol Rep 12: 1099-1103, 2004.
APA
Imai, M., Nakamura, T., Akiyama, T., & Horii, A. (2004). Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. Oncology Reports, 12, 1099-1103. https://doi.org/10.3892/or.12.5.1099
MLA
Imai, M., Nakamura, T., Akiyama, T., Horii, A."Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin". Oncology Reports 12.5 (2004): 1099-1103.
Chicago
Imai, M., Nakamura, T., Akiyama, T., Horii, A."Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin". Oncology Reports 12, no. 5 (2004): 1099-1103. https://doi.org/10.3892/or.12.5.1099
Copy and paste a formatted citation
x
Spandidos Publications style
Imai M, Nakamura T, Akiyama T and Horii A: Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. Oncol Rep 12: 1099-1103, 2004.
APA
Imai, M., Nakamura, T., Akiyama, T., & Horii, A. (2004). Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. Oncology Reports, 12, 1099-1103. https://doi.org/10.3892/or.12.5.1099
MLA
Imai, M., Nakamura, T., Akiyama, T., Horii, A."Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin". Oncology Reports 12.5 (2004): 1099-1103.
Chicago
Imai, M., Nakamura, T., Akiyama, T., Horii, A."Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin". Oncology Reports 12, no. 5 (2004): 1099-1103. https://doi.org/10.3892/or.12.5.1099
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