Fibroblast growth factor receptor 3 protein expression in urothelial carcinoma of the urinary bladder, exhibiting no association with low-grade and/or non-invasive lesions

Matsumoto,Manabu; Ohtsuki,Yuji; Ochii,Kenji; Seike,Yasushi; Iseda,Norihiro; Sasaki,Toyokazu; Okada,Yuhei; Kurabayashi,Atsushi; Furihata,Mutsuo

doi:10.3892/or.12.5.967

November 2004 Volume 12 Issue 5

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November 2004 Volume 12 Issue 5

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Article

Fibroblast growth factor receptor 3 protein expression in urothelial carcinoma of the urinary bladder, exhibiting no association with low-grade and/or non-invasive lesions

Authors:
- Manabu Matsumoto
- Yuji Ohtsuki
- Kenji Ochii
- Yasushi Seike
- Norihiro Iseda
- Toyokazu Sasaki
- Yuhei Okada
- Atsushi Kurabayashi
- Mutsuo Furihata
View Affiliations / Copyright

Affiliations: Department of Tumor Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. manabu@med.kochi-u.ac.jp
Pages: 967-971
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Published online on: November 1, 2004

https://doi.org/10.3892/or.12.5.967
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Abstract

Activating mutations of fibroblast growth factor receptor 3 (FGFR3), found in autosomal dominant human skeletal dysplasia, were reported to be involved in tumorigenesis and correlate with low-grade and superficial lesions of urothelial carcinoma. FGFR3 protein expression was immunohistochemically investigated in 126 cases of urothelial carcinoma of the urinary bladder to evaluate the role of this receptor in tumor behavior. p53 expression and the proliferating activity of tumor cells, assessed by Ki-67 expression, were also analyzed in parallel. Cytoplasmic and/or membrane immunostaining for FGFR3 was observed in 62 (49.2%) cases, including 20 (15.9%) cases of intense staining and 42 (33.3%) of moderate staining. p53 expression and Ki-67 labeling index (LI) were significantly correlated with high tumor grade (p=0.0093 and <0.0001, respectively) and invasion (p=0.0041 and <0.0001, respectively). Although there were two groups of interesting cases: low-grade and non-invasive tumors negative for p53 but positive for FGFR3, and high-grade and invasive tumors positive for p53 but negative for FGFR3, no statistically significant relationship was found between FGFR3 expression and tumor grade, invasion, p53 expression or Ki-67 LI. These results suggest that FGFR3 protein expression in bladder cancer is unlikely to affect tumor behavior as a unique single factor.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Fibroblast growth factor receptor 3 protein expression in urothelial carcinoma of the urinary bladder, exhibiting no association with low-grade and/or non-invasive lesions

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