Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality

Ito,Reiko; Nakayama,Hirofumi; Yoshida,Kazuhiro; Oda,Noriko; Yasui,Wataru

doi:10.3892/or.12.5.985

November 2004 Volume 12 Issue 5

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November 2004 Volume 12 Issue 5

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Article

Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality

Authors:
- Reiko Ito
- Hirofumi Nakayama
- Kazuhiro Yoshida
- Noriko Oda
- Wataru Yasui
View Affiliations / Copyright

Affiliations: Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8551, Japan
Pages: 985-990
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Published online on: November 1, 2004

https://doi.org/10.3892/or.12.5.985
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Abstract

Maspin, a serine protease inhibitor related to the serpin family, was originally identified in normal mammary epithelium. Reduced expression of maspin is related with development, invasion and metastasis of certain human cancers. In the present study, the expression of maspin was examined in gastric mucosa, adenoma and carcinoma by immunohistochemistry and RT-PCR. In non-neoplastic mucosa, maspin was expressed in cytoplasm and cell membrane of foveolar epithelia, fundic glandular cells and pyloric glandular cells. Maspin expression was lost in 71% (71/100) of gastric carcinomas, and in 19% (4/21) of adenomas, respectively. Loss of maspin expression was significantly associated with poorly differentiated histology, advanced stage and deep invasion (P<0.001). There was an inverse correlation between maspin expression and abnormal p53 accumulation. Maspin mRNA expression was lost in all of 8 gastric carcinoma cell lines that was retrieved after treatment with demethylation agent 5-aza-2'-deoxycytidine in 5 of 8 cell lines. These results suggest that loss of maspin expression partly due to DNA methylation may participate in tumor development and progression of gastric carcinoma in relation with p53 pathway. Loss of maspin expression may serve as a biological marker of high-grade malignancy.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality

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Abstract

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