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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2004 Volume 12 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 12 Issue 6

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Article

TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells

  • Authors:
    • Toshimasa Yatsuoka
    • Toru Furukawa
    • Makoto Sunamura
    • Seiki Matsuno
    • Akira Horii

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Tohoku University School of Medicine, Miyagi 980-8575, Japan
  • Pages: 1263-1268
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/or.12.6.1263
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Abstract

Loss of heterozygosity (LOH) on 12q is frequently observed in primary pancreatic cancer, as well as in cancers of other tissues such as stomach and germ cells. LOH correlates with poor prognosis in patients suffering from pancreatic cancer. In quest of tumor suppressor genes in this region, we used bacterial artificial chromosome (BAC) clones to construct a contig to cover one of the two targeted regions previously detected in pancreatic cancer; this region, 12B, is no larger than 650-kb between D12S360 and D12S78 at 12q22-q23.1. While constructing a detailed physical map and placing expressed sequence-tags, we identified a novel human gene, TU12B1-TY. This gene consisted of at least 14 exons and harbored an open reading frame possibly encoding a 473 amino-acid protein. A motif prediction program revealed a transmembrane domain in its carboxyl terminus. Expression in human tissues was found in the brain, placenta, skeletal muscle, pancreas, testis, uterus, and small intestine. In 21 pancreatic cancer cell lines analyzed, we found no structural alteration but all of them showed reduced expression. The present results indicate that reduced function of TU12B1-TY may contribute to the development and/or progression of human pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yatsuoka T, Furukawa T, Sunamura M, Matsuno S and Horii A: TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. Oncol Rep 12: 1263-1268, 2004.
APA
Yatsuoka, T., Furukawa, T., Sunamura, M., Matsuno, S., & Horii, A. (2004). TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. Oncology Reports, 12, 1263-1268. https://doi.org/10.3892/or.12.6.1263
MLA
Yatsuoka, T., Furukawa, T., Sunamura, M., Matsuno, S., Horii, A."TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells". Oncology Reports 12.6 (2004): 1263-1268.
Chicago
Yatsuoka, T., Furukawa, T., Sunamura, M., Matsuno, S., Horii, A."TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells". Oncology Reports 12, no. 6 (2004): 1263-1268. https://doi.org/10.3892/or.12.6.1263
Copy and paste a formatted citation
x
Spandidos Publications style
Yatsuoka T, Furukawa T, Sunamura M, Matsuno S and Horii A: TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. Oncol Rep 12: 1263-1268, 2004.
APA
Yatsuoka, T., Furukawa, T., Sunamura, M., Matsuno, S., & Horii, A. (2004). TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. Oncology Reports, 12, 1263-1268. https://doi.org/10.3892/or.12.6.1263
MLA
Yatsuoka, T., Furukawa, T., Sunamura, M., Matsuno, S., Horii, A."TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells". Oncology Reports 12.6 (2004): 1263-1268.
Chicago
Yatsuoka, T., Furukawa, T., Sunamura, M., Matsuno, S., Horii, A."TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells". Oncology Reports 12, no. 6 (2004): 1263-1268. https://doi.org/10.3892/or.12.6.1263
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