Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy

  • Authors:
    • George P. Stathopoulos
    • Sotiris K. Rigatos
    • Nicos A. Malamos
    • John G. Stathopoulos
    • Panayiota Thallasinou
    • Ekaterini Papazachariou
    • Fotini Antoniou
    • Emmanuel Kondopodis
    • John Xynotroulas
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/or.12.6.1295
  • Pages: 1295-1300
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Abstract

Our primary objective was to determine the median and overall survival and secondarily the response rate to first- and second-line chemotherapy of patients with advanced colorectal metastatic disease. Three-hundred and seventy-nine patients (median age 60 years, range 30-87 years) were enrolled from April 1993 to March 2000. Median follow-up was 6 years (range 3-10 years), until July 2003. All patients were evaluable for survival and 342 were evaluable for response and toxicity. Thirty-seven patients did not undergo chemotherapy. All patients had confirmed histology as well as metastatic disease based on radiological tests. First-line treatment was administered to 342 patients: leucovorin (LV) 30 mg/m2 and 5-fluorouracil (5-FU) 425 mg/m2. Three different combinations were given as second-line treatment during different chronological periods: i) 5-FU, mitomycin-C and doxorubicin (FAM); ii) 5-FU and cisplatin (CDDP) and iii) 5-FU, LV and irinotecan (CPT-II). Responses were observed as follows: first-line treatment 16.37%, after FAM 25%, following 5-FU-CDDP 26.83% and after 5-FU-LV-CPT-II, 30.61%. Survival of all patients was as follows: median 25 months (range 16.1-33.9 months). The longest survival was of patients on 5-FU-LV-CPT-II. Median survival of patients with stable disease was 19 months and of untreated patients 12 months. Patients with advanced colorectal cancer have a long median (25 months) and overall survival, despite low responsiveness to chemotherapy.

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December 2004
Volume 12 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stathopoulos GP, Rigatos SK, Malamos NA, Stathopoulos JG, Thallasinou P, Papazachariou E, Antoniou F, Kondopodis E and Xynotroulas J: Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy. Oncol Rep 12: 1295-1300, 2004
APA
Stathopoulos, G.P., Rigatos, S.K., Malamos, N.A., Stathopoulos, J.G., Thallasinou, P., Papazachariou, E. ... Xynotroulas, J. (2004). Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy. Oncology Reports, 12, 1295-1300. https://doi.org/10.3892/or.12.6.1295
MLA
Stathopoulos, G. P., Rigatos, S. K., Malamos, N. A., Stathopoulos, J. G., Thallasinou, P., Papazachariou, E., Antoniou, F., Kondopodis, E., Xynotroulas, J."Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy". Oncology Reports 12.6 (2004): 1295-1300.
Chicago
Stathopoulos, G. P., Rigatos, S. K., Malamos, N. A., Stathopoulos, J. G., Thallasinou, P., Papazachariou, E., Antoniou, F., Kondopodis, E., Xynotroulas, J."Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy". Oncology Reports 12, no. 6 (2004): 1295-1300. https://doi.org/10.3892/or.12.6.1295