Predicting recurrence and metastasis of stage III/Dukes' C colorectal cancer with lymph node metastasis

Mukai,Masaya; Sato,Shinkichi; Kimura,Tomomi; Ninomiya,Hiromi; Komatsu,Nobukazu; Tajima,Takayuki; Nakasaki,Hisao; Makuuchi,Hiroyasu

doi:10.3892/or.12.6.1301

December 2004 Volume 12 Issue 6

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December 2004 Volume 12 Issue 6

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Article

Predicting recurrence and metastasis of stage III/Dukes' C colorectal cancer with lymph node metastasis

Authors:
- Masaya Mukai
- Shinkichi Sato
- Tomomi Kimura
- Hiromi Ninomiya
- Nobukazu Komatsu
- Takayuki Tajima
- Hisao Nakasaki
- Hiroyasu Makuuchi
View Affiliations / Copyright

Affiliations: Department of Surgery, Tokai University Oiso Hospital, Oiso, Kanagawa 259-0198, Japan. onc-res@oiso.u-tokai.ac.jp
Pages: 1301-1304
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Published online on: December 1, 2004

https://doi.org/10.3892/or.12.6.1301
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Abstract

This study was designed to compare the prediction of recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes or using specific criteria to identify patients at high risk of recurrence/metastasis among 105 patients with Dukes' C colorectal cancer. Prediction of recurrence based on the detection of ONCs had a sensitivity of 50.0% (22/44), specificity of 80.3% (49/61), and an accuracy of 65.2%. Prediction of recurrence based on positivity for at least 2 of the 3 high-risk criteria had a sensitivity of 54.5% (24/44), specificity of 83.6% (51/61), and an accuracy of 69.1%. Among the 34 patients with ONCs, prediction of recurrence based on positivity for all 3 high-risk criteria had a sensitivity of 27.3% (6/22), specificity of 91.7% (11/12), an accuracy of 59.5%, and a positive predictive value (PPV) of 85.7% (6/7). These results suggest that the predictive value of ONCs and the high-risk criteria was similar, and that recurrence is likely to occur in patients who fulfill ≤2 of the high-risk criteria. Accordingly, combined use of these parameters may be more effective for the early prediction of recurrence/metastasis to assist in the choice of postoperative systemic chemotherapy.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Predicting recurrence and metastasis of stage III/Dukes' C colorectal cancer with lymph node metastasis

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Abstract

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