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Demonstration of the lapachol as a potential drug for reducing cancer metastasis

  • Authors:
    • Ilana Teruszkin Balassiano
    • Sheila Alves de Paulo
    • Nathalie Henriques Silva
    • Maulori Curié Cabral
    • Maria da Gloria da Costa Carvalho

  • View Affiliations

  • Published online on: February 1, 2005     https://doi.org/10.3892/or.13.2.329
  • Pages: 329-333
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Abstract

Metastasis is the major process responsible for the death in cancer patients. In the search for more effective antineoplasic drugs, many substances are under investigation, among them lapachol. This study aims to examine the molecular and morphological alterations caused by lapachol treatment, as well as its effects on the intrinsic tissue invasive property of this cell line. HeLa cells were exposed to different concentrations of lapachol, and the resulting alterations on cellular protein profile, morphology and invasiveness property were studied. At 400 µg/ml, cellular viability remains unchanged, but lapachol induces alterations in the protein profile and inhibits the invasiveness of HeLa cells in CAM model. With these results, we can conclude that lapachol has a great potential of application in fighting metastasis.

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Journal Cover

February 2005
Volume 13 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Balassiano IT, de Paulo SA, Silva NH, Cabral MC and Carvalho Md: Demonstration of the lapachol as a potential drug for reducing cancer metastasis. Oncol Rep 13: 329-333, 2005
APA
Balassiano, I.T., de Paulo, S.A., Silva, N.H., Cabral, M.C., & Carvalho, M.d. (2005). Demonstration of the lapachol as a potential drug for reducing cancer metastasis. Oncology Reports, 13, 329-333. https://doi.org/10.3892/or.13.2.329
MLA
Balassiano, I. T., de Paulo, S. A., Silva, N. H., Cabral, M. C., Carvalho, M. d."Demonstration of the lapachol as a potential drug for reducing cancer metastasis". Oncology Reports 13.2 (2005): 329-333.
Chicago
Balassiano, I. T., de Paulo, S. A., Silva, N. H., Cabral, M. C., Carvalho, M. d."Demonstration of the lapachol as a potential drug for reducing cancer metastasis". Oncology Reports 13, no. 2 (2005): 329-333. https://doi.org/10.3892/or.13.2.329