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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2005 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2005 Volume 13 Issue 4

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Article

Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients

  • Authors:
    • Shiro Hasegawa
    • Kazuhiro Seike
    • Keiji Koda
    • Nobuhiro Takiguchi
    • Kenji Oda
    • Rumiko Hasegawa
    • Masaru Miyazaki

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8677, Japan
  • Pages: 621-626
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/or.13.4.621
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Abstract

To clarify the correlation between the expression level of thymidine phosphorylase (TP) and efficacy of doxifluridine (5'-DFUR) and 5-fluorouracil (5-FU), samples from 177 colorectal cancer patients who underwent curative resection were evaluated by immunohistochemical staining using a newly developed monoclonal antibody 1C6-203. Patients were randomly given either oral 5'-DFUR or 5-FU as postoperative adjuvant chemotherapy. In Dukes' C staged colon cancer patients treated with 5'-DFUR, better survival was observed in the high TP patients than the low TP patients (p=0.025 by the log-rank test). The observed 5-year survival rates were 91.2 and 74.8%, respectively. No correlation between TP expression and patient prognosis was detected in the 5-FU group. In Dukes' C stage colon patients with high TP expression, the 5'-DFUR group had slightly better survival than the 5-FU group. These findings suggest that TP may be a chemosensitive marker for 5'-DFUR as postoperative adjuvant chemotherapy for advanced colon cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Hasegawa S, Seike K, Koda K, Takiguchi N, Oda K, Hasegawa R and Miyazaki M: Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients. Oncol Rep 13: 621-626, 2005.
APA
Hasegawa, S., Seike, K., Koda, K., Takiguchi, N., Oda, K., Hasegawa, R., & Miyazaki, M. (2005). Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients. Oncology Reports, 13, 621-626. https://doi.org/10.3892/or.13.4.621
MLA
Hasegawa, S., Seike, K., Koda, K., Takiguchi, N., Oda, K., Hasegawa, R., Miyazaki, M."Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients". Oncology Reports 13.4 (2005): 621-626.
Chicago
Hasegawa, S., Seike, K., Koda, K., Takiguchi, N., Oda, K., Hasegawa, R., Miyazaki, M."Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients". Oncology Reports 13, no. 4 (2005): 621-626. https://doi.org/10.3892/or.13.4.621
Copy and paste a formatted citation
x
Spandidos Publications style
Hasegawa S, Seike K, Koda K, Takiguchi N, Oda K, Hasegawa R and Miyazaki M: Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients. Oncol Rep 13: 621-626, 2005.
APA
Hasegawa, S., Seike, K., Koda, K., Takiguchi, N., Oda, K., Hasegawa, R., & Miyazaki, M. (2005). Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients. Oncology Reports, 13, 621-626. https://doi.org/10.3892/or.13.4.621
MLA
Hasegawa, S., Seike, K., Koda, K., Takiguchi, N., Oda, K., Hasegawa, R., Miyazaki, M."Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients". Oncology Reports 13.4 (2005): 621-626.
Chicago
Hasegawa, S., Seike, K., Koda, K., Takiguchi, N., Oda, K., Hasegawa, R., Miyazaki, M."Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients". Oncology Reports 13, no. 4 (2005): 621-626. https://doi.org/10.3892/or.13.4.621
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