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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2005 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma

  • Authors:
    • Hiroyuki Takatori
    • Shoji Natsugoe
    • Hiroshi Okumura
    • Masataka Matsumoto
    • Sumiya Ishigami
    • Tetsuhiro Owaki
    • Takashi Aikou

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
  • Pages: 697-701
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/or.13.4.697
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Abstract

Cyclooxygenase-2 (COX-2) displays anti-apoptotic functions related to angiogenesis or blocking of bcl-2 functions. COX-2 overexpression has been found in various human malignancies, including esophageal squamous cell carcinoma (ESCC). The present study examined correlations between expression of COX-2 mRNA and ESCC responses to chemoradiotherapy (CRT). Expression of COX-2 mRNA obtained from 29 biopsy specimens before CRT was quantified using reverse transcriptase-polymerase chain reaction (RT-PCR) using Sybr Green I on the Roche LightCycler system. CRT comprised 5-fluorouracil plus cisplatin and 40 Gy of radiation. Mean COX-2 mRNA score was significantly higher in tumors (1222) than in normal epithelium (50; p=0.05). Expression of COX-2 mRNA was high in 14 patients, low in 8 and absent in 7. The effective response to CRT was achieved in 18 patients. Mean COX-2 mRNA score was significantly higher in ineffective cases (2910) than in effective cases (190; p<0.05). CRT was more effective in patients with low COX-2 mRNA expression than in those with high expression. COX-2 mRNA expression in biopsy specimens was closely related to CRT effectiveness. Examination of COX-2 mRNA expression is useful for predicting the effect of CRT in patients with ESCC.

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Copy and paste a formatted citation
Spandidos Publications style
Takatori H, Natsugoe S, Okumura H, Matsumoto M, Ishigami S, Owaki T and Aikou T: Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. Oncol Rep 13: 697-701, 2005.
APA
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., & Aikou, T. (2005). Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. Oncology Reports, 13, 697-701. https://doi.org/10.3892/or.13.4.697
MLA
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., Aikou, T."Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma". Oncology Reports 13.4 (2005): 697-701.
Chicago
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., Aikou, T."Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma". Oncology Reports 13, no. 4 (2005): 697-701. https://doi.org/10.3892/or.13.4.697
Copy and paste a formatted citation
x
Spandidos Publications style
Takatori H, Natsugoe S, Okumura H, Matsumoto M, Ishigami S, Owaki T and Aikou T: Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. Oncol Rep 13: 697-701, 2005.
APA
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., & Aikou, T. (2005). Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. Oncology Reports, 13, 697-701. https://doi.org/10.3892/or.13.4.697
MLA
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., Aikou, T."Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma". Oncology Reports 13.4 (2005): 697-701.
Chicago
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., Aikou, T."Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma". Oncology Reports 13, no. 4 (2005): 697-701. https://doi.org/10.3892/or.13.4.697
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