Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma

  • Authors:
    • Hiroyuki Takatori
    • Shoji Natsugoe
    • Hiroshi Okumura
    • Masataka Matsumoto
    • Sumiya Ishigami
    • Tetsuhiro Owaki
    • Takashi Aikou
  • View Affiliations

  • Published online on: April 1, 2005     https://doi.org/10.3892/or.13.4.697
  • Pages: 697-701
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Abstract

Cyclooxygenase-2 (COX-2) displays anti-apoptotic functions related to angiogenesis or blocking of bcl-2 functions. COX-2 overexpression has been found in various human malignancies, including esophageal squamous cell carcinoma (ESCC). The present study examined correlations between expression of COX-2 mRNA and ESCC responses to chemoradiotherapy (CRT). Expression of COX-2 mRNA obtained from 29 biopsy specimens before CRT was quantified using reverse transcriptase-polymerase chain reaction (RT-PCR) using Sybr Green I on the Roche LightCycler system. CRT comprised 5-fluorouracil plus cisplatin and 40 Gy of radiation. Mean COX-2 mRNA score was significantly higher in tumors (1222) than in normal epithelium (50; p=0.05). Expression of COX-2 mRNA was high in 14 patients, low in 8 and absent in 7. The effective response to CRT was achieved in 18 patients. Mean COX-2 mRNA score was significantly higher in ineffective cases (2910) than in effective cases (190; p<0.05). CRT was more effective in patients with low COX-2 mRNA expression than in those with high expression. COX-2 mRNA expression in biopsy specimens was closely related to CRT effectiveness. Examination of COX-2 mRNA expression is useful for predicting the effect of CRT in patients with ESCC.

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April 2005
Volume 13 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takatori H, Natsugoe S, Okumura H, Matsumoto M, Ishigami S, Owaki T and Aikou T: Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. Oncol Rep 13: 697-701, 2005
APA
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., & Aikou, T. (2005). Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. Oncology Reports, 13, 697-701. https://doi.org/10.3892/or.13.4.697
MLA
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., Aikou, T."Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma". Oncology Reports 13.4 (2005): 697-701.
Chicago
Takatori, H., Natsugoe, S., Okumura, H., Matsumoto, M., Ishigami, S., Owaki, T., Aikou, T."Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma". Oncology Reports 13, no. 4 (2005): 697-701. https://doi.org/10.3892/or.13.4.697