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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2005 Volume 13 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters

  • Authors:
    • Yuri Izumiyama
    • Yoichi Ohiro
    • Fumihiro Higashino
    • Koichi Yoshida
    • Kazunori Taguchi
    • Satoru Todo
    • Takao Kohgo
    • Yasunori Totsuka
    • Masanobu Shindoh

  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita-Ku, Sapporo 060-8586, Japan
  • Pages: 715-720
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/or.13.4.715
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Abstract

E1AF is an ets-oncogene family transcription factor that has been shown to up-regulate multiple MMPs whereas MMP-2, a potent extracellular matrix degrading enzyme, is not up-regulated. We investigated the activation mechanism of MMP-2 in oral squamous cell carcinoma. Chloramphenicol acetyltransferase (CAT) assay was utilized to investigate whether E1AF is able to up-regulate membrane type-1 matrix metalloproteinase (MT1-MMP), which is known to activate MMP-2. Expression of the CAT reporter gene under the control of the MT1-MMP promoter was increased approximately 40-fold by co-transfection with the E1AF expression vector. Real-time RT-PCR study was carried out in 25 patients with tongue squamous cell carcinoma, and the mRNA expression level of E1AF and MT1-MMP was synergistically increased. These results indicate that E1AF positively regulates tran-scription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2.

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Copy and paste a formatted citation
Spandidos Publications style
Izumiyama Y, Ohiro Y, Higashino F, Yoshida K, Taguchi K, Todo S, Kohgo T, Totsuka Y and Shindoh M: E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters. Oncol Rep 13: 715-720, 2005.
APA
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S. ... Shindoh, M. (2005). E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters. Oncology Reports, 13, 715-720. https://doi.org/10.3892/or.13.4.715
MLA
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S., Kohgo, T., Totsuka, Y., Shindoh, M."E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters". Oncology Reports 13.4 (2005): 715-720.
Chicago
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S., Kohgo, T., Totsuka, Y., Shindoh, M."E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters". Oncology Reports 13, no. 4 (2005): 715-720. https://doi.org/10.3892/or.13.4.715
Copy and paste a formatted citation
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Spandidos Publications style
Izumiyama Y, Ohiro Y, Higashino F, Yoshida K, Taguchi K, Todo S, Kohgo T, Totsuka Y and Shindoh M: E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters. Oncol Rep 13: 715-720, 2005.
APA
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S. ... Shindoh, M. (2005). E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters. Oncology Reports, 13, 715-720. https://doi.org/10.3892/or.13.4.715
MLA
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S., Kohgo, T., Totsuka, Y., Shindoh, M."E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters". Oncology Reports 13.4 (2005): 715-720.
Chicago
Izumiyama, Y., Ohiro, Y., Higashino, F., Yoshida, K., Taguchi, K., Todo, S., Kohgo, T., Totsuka, Y., Shindoh, M."E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters". Oncology Reports 13, no. 4 (2005): 715-720. https://doi.org/10.3892/or.13.4.715
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