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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2005 Volume 14 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions

  • Authors:
    • Ilaria Lampronti
    • Nicoletta Bianchi
    • Monica Borgatti
    • Enrica Fabbri
    • Leonardo Vizziello
    • Mahmud Tareq Hassan Khan
    • Arjumand Ather
    • Dan Brezena
    • Mohammad Mahroof Tahir
    • Roberto Gambari

  • View Affiliations / Copyright

    Affiliations: ER-GenTech, Department of Biochemistry and Molecular Biology, Section of Molecular Biology, Ferrara University, Ferrara, Italy
  • Pages: 9-15
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/or.14.1.9
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Abstract

Vanadium complexes are known to possess potent insulin-mimetic effects, high affinity for several enzymes and anticancer activity, which deserve increasing attention for application to biomedical sciences. Different vanadium complexes have been found to be more effective than the simple vanadium-(IV) and -(V) salts in experiments performed both in vitro and in vivo. Application of polyoxometalates as potential drugs against Herpes Simplex Virus and AIDS have also increased the interest to study the association between vanadium containing species and proteins. The aim of our research was to investigate the in vitro antiproliferative activity of a variety of vanadium-containing compounds, and study their ability to interfere with the molecular interactions between GATA-1 and NF-κB transcription factors and target DNA elements, employing electrophoretic mobility shift assays. All of the used vanadium compounds were found to exhibit antiproliferative activity, despite with differences in efficacy. Inhibition of K562 cell growth was not associated with differentiation, but with activation of apoptosis. Vanadium complexes with a +5 oxidation state and their discrete anionic units appear essential for the respective effects on K562 cells; a +4 oxidation state appears to be important in inhibiting transcription factors/DNA interactions.

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Copy and paste a formatted citation
Spandidos Publications style
Lampronti I, Bianchi N, Borgatti M, Fabbri E, Vizziello L, Khan MT, Ather A, Brezena D, Tahir MM, Gambari R, Gambari R, et al: Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions. Oncol Rep 14: 9-15, 2005.
APA
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M.T. ... Gambari, R. (2005). Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions. Oncology Reports, 14, 9-15. https://doi.org/10.3892/or.14.1.9
MLA
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M. T., Ather, A., Brezena, D., Tahir, M. M., Gambari, R."Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions". Oncology Reports 14.1 (2005): 9-15.
Chicago
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M. T., Ather, A., Brezena, D., Tahir, M. M., Gambari, R."Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions". Oncology Reports 14, no. 1 (2005): 9-15. https://doi.org/10.3892/or.14.1.9
Copy and paste a formatted citation
x
Spandidos Publications style
Lampronti I, Bianchi N, Borgatti M, Fabbri E, Vizziello L, Khan MT, Ather A, Brezena D, Tahir MM, Gambari R, Gambari R, et al: Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions. Oncol Rep 14: 9-15, 2005.
APA
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M.T. ... Gambari, R. (2005). Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions. Oncology Reports, 14, 9-15. https://doi.org/10.3892/or.14.1.9
MLA
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M. T., Ather, A., Brezena, D., Tahir, M. M., Gambari, R."Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions". Oncology Reports 14.1 (2005): 9-15.
Chicago
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M. T., Ather, A., Brezena, D., Tahir, M. M., Gambari, R."Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions". Oncology Reports 14, no. 1 (2005): 9-15. https://doi.org/10.3892/or.14.1.9
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