Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions

  • Authors:
    • Ilaria Lampronti
    • Nicoletta Bianchi
    • Monica Borgatti
    • Enrica Fabbri
    • Leonardo Vizziello
    • Mahmud Tareq Hassan Khan
    • Arjumand Ather
    • Dan Brezena
    • Mohammad Mahroof Tahir
    • Roberto Gambari
  • View Affiliations

  • Published online on: July 1, 2005     https://doi.org/10.3892/or.14.1.9
  • Pages: 9-15
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Abstract

Vanadium complexes are known to possess potent insulin-mimetic effects, high affinity for several enzymes and anticancer activity, which deserve increasing attention for application to biomedical sciences. Different vanadium complexes have been found to be more effective than the simple vanadium-(IV) and -(V) salts in experiments performed both in vitro and in vivo. Application of polyoxometalates as potential drugs against Herpes Simplex Virus and AIDS have also increased the interest to study the association between vanadium containing species and proteins. The aim of our research was to investigate the in vitro antiproliferative activity of a variety of vanadium-containing compounds, and study their ability to interfere with the molecular interactions between GATA-1 and NF-κB transcription factors and target DNA elements, employing electrophoretic mobility shift assays. All of the used vanadium compounds were found to exhibit antiproliferative activity, despite with differences in efficacy. Inhibition of K562 cell growth was not associated with differentiation, but with activation of apoptosis. Vanadium complexes with a +5 oxidation state and their discrete anionic units appear essential for the respective effects on K562 cells; a +4 oxidation state appears to be important in inhibiting transcription factors/DNA interactions.

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July 2005
Volume 14 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lampronti I, Bianchi N, Borgatti M, Fabbri E, Vizziello L, Khan MT, Ather A, Brezena D, Tahir MM, Gambari R, Gambari R, et al: Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions. Oncol Rep 14: 9-15, 2005
APA
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M.T. ... Gambari, R. (2005). Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions. Oncology Reports, 14, 9-15. https://doi.org/10.3892/or.14.1.9
MLA
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M. T., Ather, A., Brezena, D., Tahir, M. M., Gambari, R."Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions". Oncology Reports 14.1 (2005): 9-15.
Chicago
Lampronti, I., Bianchi, N., Borgatti, M., Fabbri, E., Vizziello, L., Khan, M. T., Ather, A., Brezena, D., Tahir, M. M., Gambari, R."Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions". Oncology Reports 14, no. 1 (2005): 9-15. https://doi.org/10.3892/or.14.1.9