Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa

  • Authors:
    • Hideo Takekoshi
    • Toru Mizoguchi
    • Yoko Komasa
    • Hirofumi Chubachi
    • Yukari Inoue
    • Hideyo Imanishi
    • Masuo Nakano
  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/or.14.2.409
  • Pages: 409-414
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Abstract

The modifying effects of dietary administration of dried Chlorella pyrenoidosa powder (C. pyrenoidosa) on the development of glutathione S-transferase placental form-positive foci (GST-P-positive foci), which are putative preneoplastic lesions, in male F344 rats were investigated using a medium-term liver bioassay system. In rats given 10% C. pyrenoidosa in a basal diet, the number and area of GST-P-positive foci in the rat livers, which diethylnitrosamine (DEN) initiated and 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) promoted, were significantly decreased compared with those fed a basal diet not containing C. pyrenoidosa. The inhibition percentage of the number and area of GST-P-positive foci ≥0.2 mm in diameter was 67.6 and 74.2%, respectively (p<0.01). Furthermore, C. pyrenoidosa significantly decreased the number of GST-P-positive foci induced by MeIQx alone. The inhibition percentage of the number of GST-P-positive foci <0.2 mm in diameter was 52% (p<0.01). These results suggest that C. pyrenoidosa has chemopreventive effects against hepatocarcinogenesis in rats. C. pyrenoidosa appears to be a promising chemopreventive agent for human liver neoplasia and carcinogenesis induced by heterocyclic amines such as MeIQx.

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August 2005
Volume 14 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takekoshi H, Mizoguchi T, Komasa Y, Chubachi H, Inoue Y, Imanishi H and Nakano M: Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa. Oncol Rep 14: 409-414, 2005
APA
Takekoshi, H., Mizoguchi, T., Komasa, Y., Chubachi, H., Inoue, Y., Imanishi, H., & Nakano, M. (2005). Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa. Oncology Reports, 14, 409-414. https://doi.org/10.3892/or.14.2.409
MLA
Takekoshi, H., Mizoguchi, T., Komasa, Y., Chubachi, H., Inoue, Y., Imanishi, H., Nakano, M."Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa". Oncology Reports 14.2 (2005): 409-414.
Chicago
Takekoshi, H., Mizoguchi, T., Komasa, Y., Chubachi, H., Inoue, Y., Imanishi, H., Nakano, M."Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa". Oncology Reports 14, no. 2 (2005): 409-414. https://doi.org/10.3892/or.14.2.409