A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan

  • Authors:
    • Kazuya Kuraoka
    • Shunji Matsumura
    • Yuichi Sanada
    • Kei Nakachi
    • Kazue Imai
    • Hidetaka Eguchi
    • Keisuke Matsusaki
    • Naohide Oue
    • Hirofumi Nakayama
    • Wataru Yasui
  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/or.14.2.465
  • Pages: 465-470
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Abstract

Death receptor 4 (DR4) is a member of the tumor necrosis factor-related apoptosis-inducing ligand receptor genes. A single nucleotide polymorphism (Thr or Arg, C or G) in the extracellular domain was reported to be associated with a risk of lung cancer, head and neck cancer, and bladder cancer. In this study, we examined the association between the DR4 polymorphism and gastric cancer. The Thr/Thr, Thr/Arg and Arg/Arg genotypes were found in 250 (91.2%), 23 (8.4%) and 1 (0.4%) of 274 gastric cancer patients and in 317 (92.2%), 21 (6.1%) and 6 (1.7%) of 344 control subjects, respectively. The OR of Thr/Arg or Arg/Arg genotype did not reveal a significantly enhanced risk of 1.13 (95% CI, 0.63-2.00) compared to Thr/Thr genotype, suggesting that the DR4 polymorphism did not modify the risk of gastric cancer. In patients, no association between the genotype and clinicopathological characteristics (depth of invasion, lymph node metastasis, distant metastasis, stage and grade of differentiation) of gastric carcinoma was found. DR4 was constantly expressed in gastric carcinoma, but not in non-neoplastic gastric epithelium in immunohistochemistry. In conclusion, a Thr to Arg single nucleotide polymorphism in the extracellular domain of DR4 could not be associated with the development and progression of gastric cancer.

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August 2005
Volume 14 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kuraoka K, Matsumura S, Sanada Y, Nakachi K, Imai K, Eguchi H, Matsusaki K, Oue N, Nakayama H, Yasui W, Yasui W, et al: A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. Oncol Rep 14: 465-470, 2005
APA
Kuraoka, K., Matsumura, S., Sanada, Y., Nakachi, K., Imai, K., Eguchi, H. ... Yasui, W. (2005). A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. Oncology Reports, 14, 465-470. https://doi.org/10.3892/or.14.2.465
MLA
Kuraoka, K., Matsumura, S., Sanada, Y., Nakachi, K., Imai, K., Eguchi, H., Matsusaki, K., Oue, N., Nakayama, H., Yasui, W."A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan". Oncology Reports 14.2 (2005): 465-470.
Chicago
Kuraoka, K., Matsumura, S., Sanada, Y., Nakachi, K., Imai, K., Eguchi, H., Matsusaki, K., Oue, N., Nakayama, H., Yasui, W."A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan". Oncology Reports 14, no. 2 (2005): 465-470. https://doi.org/10.3892/or.14.2.465